CompletedPhase 4ketamine

Low Dose Ketamine for Blunt Thoracic Trauma

NCT ID

NCT06236113

Target Enrollment

50 participants

Start Date

2021-10-01

Est. Completion

2023-06-26

About This Study

The goal of this Randomized controlled double-blinded trial is to compare the addition of a ketamine infusion to placebo, when added to standard care in adult blunt trauma patients with multiple rib fractures. The main question it aims to answer are: • addition of low dose ketamine infusion (LDKI) decreases narcotic use • does LDKI impact pulmonary complications, readmission, or hospital length of stay Participants will receive usual standard of care with up to 48 hours of LDKI or placebo. If there is a comparison group: Researchers will compare infusion of a saline infusion to LDKI to see if LDKI decreases need for narcotic analgesics use.

Conditions Studied

Blunt Injury of ThoraxMultiple Rib Fractures, Involving Three Ribs

Interventions

•Ketamine 1 Mg/mL-NaCl 0.9% Intravenous Solution

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Males or females 18 years of age or older
* Diagnosis of 3 or more acute rib fractures related to blunt traumatic chest injury.
* Able to undergo consent procedure and give valid consent, or availability of family member to provide consent for the study

Exclusion Criteria:

* Age \<18 years
* Cognitively impaired
* Pregnant or lactating females.
* Glasgow Coma Score (GCS) of ≤ 14 at time of admission
* Evidence of increased intraocular pressure
* Presence of acute coronary syndrome
* Diagnosed moderate to severe traumatic brain injury
* Evidence of uncontrolled intracranial hypertension
* History of seizures or stroke
* History of severe psychiatric disorders
* Allergy to ketamine
* Currently being treated, prior to admission, with opiate agonist/antagonist therapy
* Presence of poorly controlled hypertension, cardiac arrhythmias, and/or tachycardia on admission
* Subjects who, in the opinion of the Investigator, may be inappropriate for study participation.

Study Locations (1)

North Memorial Health Hospital

Robbinsdale, Minnesota, United States