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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 769816 of 1695 trials
Completed·Phase 1·ketamine

Pharmacokinetics and Pharmacodynamics of Nasally Applied Esketamine

University Hospital, Basel, Switzerland

Pain
Completed·Phase 2·ketamine

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Dennis Charney

Stress Disorders, Post-TraumaticPTSDDepression+1 more
Completed·Phase 4·Other

Methadone Versus Morphine for Orthopedic Surgery Patients

University of Louisville

FracturePain, Postoperative
Completed·N/A·MDMA

Clinical Pharmacology of MDA [3,4-methylenedioxyamphetamine]

California Pacific Medical Center Research Institute

Healthy
Completed·N/A·ketamine

Ketamine Associated With Morphine PCA After Total Hip Arthroplasty

Assistance Publique - Hôpitaux de Paris

Arthroplasty, Replacement, Hip
Completed·Phase 2·ketamine

Optimization of IV Ketamine for Treatment Resistant Depression

Baylor College of Medicine

Major Depressive Disorder (MDD)Treatment Resistant Depression (TRD)
Completed·N/A·ketamine

Effect of Ketamine on Opioid-Induced Hyperalgesia

Massachusetts General Hospital

PainChronic PainHyperalgesia
Completed·N/A·psilocybin

Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study

Johns Hopkins University

Nicotine Dependence
Completed·Phase 4·ketamine

Prevention of Persistent Postsurgical Pain After Thoracotomy

Hospital Clinic of Barcelona

Persistent PainPostoperative Hyperalgesia
Completed·Phase 4·ketamine

Efficacy Study of Ketamine for Postoperative Pain in Opioid Dependent Patients

Brigham and Women's Hospital

Postoperative Pain
Completed·N/A·ketamine

The Effects of Ketamine and Guanfacine on Working Memory in Healthy Subjects

Yale University

NMDA Receptor Function
Completed·N/A·DMT

Neuroendocrine Mechanisms of Developmental Massage Therapy (DMT) in Preterm Infants: Clinical Study

University of Utah

Premature Birth of Newborn
Completed·Phase 3·ketamine

Safety and Efficacy of Repeated Doses of PMI-150 (Intranasal Ketamine) in Acute Post-operative Pain Following Orthopedic Surgery

Hospira, now a wholly owned subsidiary of Pfizer

Pain, Postoperative
Completed·Phase 3·ketamine

Pain Medicine for Wound Care Procedures

University of California, San Francisco

Wound CarePain IntensityHyperalgesia+3 more
Completed·Phase 3·ketamine

Neuropathic Pain Caused by Radiation Therapy

British Columbia Cancer Agency

Neuropathic Pain Secondary to Radiation Therapy
Completed·N/A·ketamine

Neurophysiology and Pharmacology of Cough Reflex Hypersensitivity

Jacky Smith

Chronic Cough
Completed·Phase 3·ketamine

Baclofen-Amitriptyline Hydrochloride-Ketamine Gel in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer

Alliance for Clinical Trials in Oncology

Chronic Myeloproliferative DisordersLeukemiaLymphoma+7 more
Completed·Phase 2·LSD

Lysergic Acid Diethylamide (LSD)-Assisted Psychotherapy in People With Illness-related Anxiety

Multidisciplinary Association for Psychedelic Studies

Anxiety
Completed·Phase 1·ketamine

Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects

Yale University

Healthy
Completed·Phase 1·ketamine

Parallel Effects of Schizophrenia and N-methyl-D-aspartate (NMDA) Antagonism

Yale University

Schizophrenia
Completed·Phase 1·ketamine

Assessing the Effects of a Nasal Corticosteroid on PMI-150 (Intranasal Ketamine)

Javelin Pharmaceuticals

Healthy
Completed·Phase 1·Other

Activated White Blood Cells With ASCT for Newly Diagnosed Multiple Myeloma

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Multiple Myeloma and Plasma Cell Neoplasm
Completed·Phase 2·ketamine

The Effect of Perioperative Ketamine on Acute and Chronic Pain After Major Back Surgery

University Hospital, Geneva

Postoperative Pain
Completed·Phase 3·ketamine

Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Cancer Patients

Gary Morrow

NeurotoxicityPainPeripheral Neuropathy+1 more
Completed·N/A·ketamine

The Effect of Etomidate on Patient Outcomes After Single Bolus Doses

Advocate Hospital System

SepsisTrauma
Completed·Phase 1·ketamine

Continuation Ketamine in Major Depression

James Murrough

Major Depressive Disorder
Completed·N/A·ketamine

Ketamine Compared to Propofol for Pediatric GI Endoscopy

State University of New York - Upstate Medical University

Endoscopy
Completed·N/A·ketamine

Pharmacokinetics of Ketamine in Infants and Children

Stanford University

The Pk of IV Ketamine in Children With Heart Disease
Completed·Phase 2·ketamine

Ketamine In Thoracic Surgery (KITS) Trial

Duke University

Lung Cancer
Completed·Phase 4·ketamine

Propofol Versus Ketamine for Moderate Procedural Sedation in the Emergency Department (ED)

Hennepin Healthcare Research Institute

Sedation
Completed·Phase 1·ketamine

Absolute Bioavailability and Nasopharyngeal Absorption of Intranasal Ketamine

Javelin Pharmaceuticals

Healthy
Completed·Phase 4·ketamine

Ketamine/Propofol vs Ketamine Alone for Pediatric Fracture Reduction

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Fractures
Completed·Phase 1·ketamine

Multiple Dose Pharmacokinetics of Intranasal Ketamine

Javelin Pharmaceuticals

Healthy
Completed·Phase 3·ketamine

Ketamine Associated With Opioids in Refractory Cancer Pain Treatment

Assistance Publique - Hôpitaux de Paris

Pain
Completed·Phase 2·ketamine

Intranasal Ketamine for Procedural Sedation in Pediatric Laceration Repair

Rhode Island Hospital

Laceration
Completed·Phase 4·ketamine

Ketamine Versus Etomidate During Rapid Sequence Intubation: Consequences on Hospital Morbidity

Assistance Publique - Hôpitaux de Paris

Intubation; Difficult
Completed·Phase 2·psilocybin

Psychopharmacology of Psilocybin in Cancer Patients

Johns Hopkins University

Depressive SymptomsAnxietyCancer
Completed·N/A·ketamine

Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain

Dartmouth-Hitchcock Medical Center

Chronic Low Back Pain
Completed·Phase 1·Other

GABA-glutamate Interactions and Psychosis

Yale University

Cognitive Dysfunction
Completed·Phase 4·ketamine

Research Study for Major Depressive Disorder: Investigation of Glutamate Medications

Baylor College of Medicine

Major Depression
Completed·Phase 3·DMT

The Influence of Vibration on Bone Mineral Density in Women Who Have Weak Bones After Menopause

University Health Network, Toronto

Bone DensityOsteopeniaOsteoporosis+1 more
Completed·Phase 2·MDMA

Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder

Lykos Therapeutics

Posttraumatic Stress Disorder
Completed·Phase 2·ketamine

Double Blind Placebo Controlled Study of Outpatient Intravenous Ketamine for the Treatment of CRPS

Drexel University College of Medicine

Complex Regional Pain Syndrome
Completed·N/A·ketamine

Low Dose Ketamine as an Adjunct to Fentanyl in Outpatient Tonsillectomy

Mayo Clinic

Pain
Completed·Phase 4·ketamine

Effect of Perioperative i.v. Low-dose S(+) Ketamine

Asker & Baerum Hospital

HemorrhoidsPain
Completed·Phase 4·ketamine

Ketamine Versus Etomidate for Procedural Sedation for Pediatric Orthopedic Reductions

Drexel University College of Medicine

Conscious Sedation Failure During Procedure
Completed·N/A·ketamine

Does a Single Intravenous Dose of Ketamine Reduce the Need for Supplemental Opioids in Post-Cesarean Section Patients?

Northwestern University

Ketamine Adverse ReactionEffects of; Anesthesia, Spinal and Epidural, in PregnancyComplication of Labor and/or Delivery
Completed·Phase 4·ketamine

Memantine Augmentation of Antidepressants

University of Massachusetts, Worcester

Depressive Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.