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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 4996 of 1695 trials
Active, Not Recruiting·Phase 3·ketamine

Opiate Suicide Study in Patients With Major Depression

Stanford University

Major Depressive Disorder
Active, Not Recruiting·N/A·psilocybin

Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment

University Hospital, Geneva

Major Depressive Disorder (MDD)Anxiety DisordersSubstance Use Disorder (SUD)+1 more
Active, Not Recruiting·Phase 3·ketamine

Perioperative Lidocaine and Ketamine in Abdominal Surgery

The Cleveland Clinic

Postoperative Pain
Active, Not Recruiting·Phase 3·DMT

Disease Modifying Therapies Withdrawal in Inactive Secondary Progressive Multiple Sclerosis Patients Older Than 50 Years (STOP-I-SEP)

Rennes University Hospital

Multiple Sclerosis
Active, Not Recruiting·Early Phase 1·ketamine

Ketamine Associated ACC GABA and Glutamate Change and Depression Remission:

Mayo Clinic

Major Depressive DisorderTreatment Resistant DepressionBipolar Depression
Active, Not Recruiting·Phase 1·psilocybin

Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder

Yale University

Major Depressive Disorder
Active, Not Recruiting·Phase 3·Other

Facilitating Rapid Naltrexone Initiation

New York State Psychiatric Institute

Opioid Dependence
Active, Not Recruiting·Phase 3·ketamine

Intranasal Ketamine as an Adjunct to Fentanyl for the Prehospital Treatment of Acute Traumatic Pain

Jason McMullan

Acute Traumatic Pain
Active, Not Recruiting·Phase 2·ketamine

Understanding How Ketamine Brings About Rapid Improvement in OCD

Stanford University

Obsessive-Compulsive Disorder
Approved for Marketing·N/A·LSD

BMN 110 US Expanded Access Program

BioMarin Pharmaceutical

Mucopolysaccharidosis IVAMorquio A SyndromeMPS IVA
Approved for Marketing·N/A·ketamine

Pre-Approval Access to Esketamine Nasal Spray for the Treatment of Treatment-Resistant Depression (TRD)

Janssen Research & Development, LLC

Depressive Disorder, Treatment-Resistant
Completed·Phase 4·ketamine

The Nonirritating Concentrations of Midazolam, Ketamine, and Ondansetron

Mayo Clinic

Allergy
Completed·Phase 1·psilocybin

A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers

MycoMedica Life Sciences PBC

Healthy Volunteer
Completed·N/A·Other

Outcome of Multimodal Anesthesia Bern

Insel Gruppe AG, University Hospital Bern

Opioid UsePain, PostoperativePostoperative Complications+1 more
Completed·Phase 1·ketamine

Combining Esketamine and Prolonged Exposure Treatment for PTSD (Post Traumatic Stress Disorder)

The University of Texas Health Science Center at San Antonio

Post Traumatic Stress Disorder PTSD
Completed·N/A·Other

A Real-world Study of Disease-modifying Therapy Treatment Outcomes in Patients With Spinal Muscular Atrophy

Novartis Pharmaceuticals

Muscular Atrophy, Spinal
Completed·N/A·DMT

Dance Movement Therapy for Radio-oncological Patients

University of Erlangen-Nürnberg Medical School

Cancer Patients and Physical Activity
Completed·Phase 1·ketamine

Acute Analgesic Effects of DMT on Experimentally Induced Pain in Healthy Participants

University Hospital, Basel, Switzerland

Healthy
Completed·N/A·psilocybin

Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures

Centre Hospitalier Universitaire de Nīmes

Psychogenic Nonepileptic SeizuresPsilocybin
Completed·Phase 1·ketamine

KF2024#1-trial: Esketamine Interaction Study

Helsinki University Central Hospital

Drug InteractionsFood-drug Interaction
Completed·N/A·psilocybin

Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression

Centre Hospitalier Universitaire de Nīmes

Depressive DisorderDepressive Disorder, Treatment-ResistantHallucinogens+1 more
Completed·Phase 1·psilocybin

A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic Cancer

University of Washington

Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·Phase 2·ketamine

FMRI of Patients Receiving IV Ketamine for Treatment Resistant Bipolar Depression

Brian Barnett

Bipolar DepressionTreatment Resistant Bipolar Depression
Completed·N/A·Other

A Study of Dosing Patterns and Costs in Patients With Spinal Muscular Atrophy Receiving Disease Modifying Therapies

Novartis Pharmaceuticals

Muscular Atrophy, Spinal
Completed·N/A·ketamine

Effect of Ketamine, Amitriptyline and Their Combination on Itch

Aalborg University

Itch
Completed·N/A·LSD

Salivary Oxytocin as a Biomarker in Psychedelic Assisted Psychotherapy

Tatiana Aboulafia Brakha

Depression, Anxiety
Completed·N/A·psilocybin

Low-Income Group Psilocybin Assisted Therapy for Depression

Matthew Hicks

Depression
Completed·N/A·ketamine

Use of Ketamine in Severe Pain Syndromes

Erasme University Hospital

Pain, IntractablePain, ChronicPain Syndrome+1 more
Completed·N/A·ketamine

(GluEsk) Glutamate and Esketamine

University of Oxford

Depression
Completed·Phase 1·DMT

Acute Dose-dependent Effects of DMT-bolus Applications in Healthy Subjects (DMT BDR-Study)

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 2·Other

Safety, Tolerability, Analgesic Effect, and Feasibility of Intranasal CT001 in Pediatric Patients

Cessatech A/S

Pain
Completed·N/A·ketamine

Opioid-based Versus Opioid-free Endotracheal Intubation

Aretaieion University Hospital

AnesthesiaAnesthesia IntubationOpioid Use+2 more
Completed·N/A·ketamine

Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State

Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer

Depressive Disorder
Completed·Phase 2·ketamine

A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder

Clexio Biosciences Ltd.

Adjunctive Treatment of Major Depressive Disorder (MDD)
Completed·N/A·Other

Comparison of Total Intravenous Anesthesia and Inhalational Anesthesia in Opioid-Free Anesthesia for Bariatric Surgery: A Randomized Controlled Trial

Jagiellonian University

Analgesics, OpioidAnesthesia; Adverse Effect
Completed·N/A·LSD

LSD-Perceptual-Choice-Study

University Hospital, Basel, Switzerland

LSD Reaction
Completed·N/A·psilocybin

Psilocybin in Alcohol Use Disorder With Comorbid Depression

Centre Hospitalier Universitaire de Nīmes

Alcohol-Related DisordersDepressive DisorderAddiction
Completed·Phase 1·LSD

Effect of Ketanserin, Olanzapine, and Lorazepam After LSD Administration on the Acute Response to LSD in Healthy Subjects

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·ayahuasca

Molecular Imaging Study of Harmine/DMT: a Basic Research Approach

Insel Gruppe AG, University Hospital Bern

Neuropharmacological Investigation of Ayahuasca Constituents DMT and Harmine
Completed·Early Phase 1·ketamine

Ketamine for MS Fatigue

Alta Bates Summit Medical Center

Multiple Sclerosis
Completed·N/A·ketamine

Sustained Ketamine Effectiveness for Suicidal Ideation

University Hospital, Montpellier

Depression - Major Depressive DisorderSuicide
Completed·Phase 1·MDMA

Acute Effects of 3,4-methylenedioxymethamphetamine (MDMA) With and Without a Booster Dose

University Hospital, Basel, Switzerland

Healthy
Completed·Phase 1·psilocybin

Consciousness, Psilocybin, and Well-Being

University of Wisconsin, Madison

HealthyPsychedelic ExperiencesSleep
Completed·Phase 2·psilocybin

Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

University of Chicago

Borderline Personality DisorderMajor Depressive Disorder
Completed·Phase 3·Other

COnventional Vs. Optimised PERiprocedural Analgosedation Vs. Total IntraVEnous Anaesthesia for Pulsed-Field Ablation (COOPERATIVE-PFA)

Charles University, Czech Republic

Atrial Fibrillation
Completed·Phase 1·psilocybin

Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans

University of Zurich

Healthy
Completed·N/A·ketamine

Standardised Drug Provocation Testing in Perioperative Hypersensitivity

University Hospital, Antwerp

Allergic ReactionHypersensitivityPerioperative Complication+4 more
Completed·Phase 4·ketamine

Psychotherapy for Ketamine's Enhanced Durability in Chronic Neuropathic Pain: A Randomized Controlled Pilot Trial

Unity Health Toronto

Neuropathic Pain
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.