132 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 1–48 of 261 trials
Active, Not Recruiting·N/A·psilocybin
Observational Pilot Study to Explore the Social and Health Impacts of a New Model of Care in Oregon: Psilocybin Services on Alcoholism
Healing Advocacy Fund
Alcohol Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Active, Not Recruiting·Phase 1·psilocybin
A Study of Psilocybin for PTSD
Johns Hopkins University
Post Traumatic Stress Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer
University Health Network, Toronto
Advanced CancerStage IV Solid Tumor CancerStage IV Sarcoma of Bone+3 more
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted vs Ketamine-Assisted Psychotherapy for Alcohol Use Disorder
Peggy C Nopoulos
Alcohol Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
Assessment of Psilocybin (TRP-8802) in Concert With Psychotherapy in Patients With Irritable Bowel Syndrome (IBS)
TRYP Therapeutics
Irritable Bowel Syndrome
Active, Not Recruiting·Phase 2·psilocybin
Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment
Centre for Addiction and Mental Health
Amnestic Mild Cognitive Impairment
Active, Not Recruiting·Phase 1·psilocybin
Neural and Physiological Correlates of Psychedelic Sub-states
Robin Carhart-Harris, PhD, MA
Psychedelic ExperiencesNeuroimagingHealthy Volunteers
Active, Not Recruiting·Phase 1·psilocybin
Effects of Repeated Psilocybin Dosing in OCD
Yale University
Obsessive-Compulsive Disorder
Active, Not Recruiting·Phase 1·psilocybin
Palliadelic Treatment to Reduce Psychological Distress in Persons With Advanced Gastrointestinal Cancers
University of Nebraska
Pancreas CancerBiliary Tract CancerPsychological Distress+1 more
Active, Not Recruiting·Phase 1·psilocybin
Study of the Safety and Feasibility of Psilocybin in Adults With Methamphetamine Use Disorder
University of Wisconsin, Madison
Methamphetamine Use DisorderSubstance-Related DisordersChemically-Induced Disorders+2 more
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of Two Administrations of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment of Alcohol Use Disorder: a Feasibility Study
Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder (AUD)
Active, Not Recruiting·Phase 2·psilocybin
A Phase II, Multicentre, Randomised, Double-blind, Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Efficacy of COMP360 in Participants With Recurrent Major Depressive Disorder
COMPASS Pathways
Major Depressive Disorder
Active, Not Recruiting·Phase 3·psilocybin
Efficacy, Safety, and Tolerability of COMP360 in Participants With TRD
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for the Treatment of Veterans With Post-Traumatic Stress Disorder
Ohio State University
PTSDStress Disorders, TraumaticStress Disorders, Post-Traumatic+2 more
Active, Not Recruiting·Early Phase 1·psilocybin
Effects of Psilocybin in Obsessive Compulsive Disorder
Johns Hopkins University
Obsessive-Compulsive Disorder
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Active, Not Recruiting·Phase 1·psilocybin
Comparing the Effects of Psilocin and Psilocybin in Healthy Adults
University of California, San Francisco
Healthy
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Therapy for Depression in Bipolar II Disorder
University of California, San Francisco
Bipolar II Disorder
Active, Not Recruiting·N/A·psilocybin
Measurement of Serum Inflammatory Markers in Patients Treatment-resistant Depression Given Psilocybin
King's College London
Depression - Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Johns Hopkins University
Major Depressive DisorderAlcohol Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Active, Not Recruiting·Phase 2·psilocybin
Pilot Trial of Visual Healing® in Psilocybin-assisted Therapy for Alcohol Use Disorder
Keith Heinzerling
Alcohol Use Disorder
Active, Not Recruiting·N/A·psilocybin
Retrospective Observational Study of Intensity Effects in Psychedelic-assisted Treatment
University Hospital, Geneva
Major Depressive Disorder (MDD)Anxiety DisordersSubstance Use Disorder (SUD)+1 more
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Yale University
Major Depressive Disorder
Completed·Phase 1·psilocybin
A Study Assessing Brain Activity, Safety, Tolerability, and Pharmacokinetics Following Multiple Doses of MLS101 (Psilocybin) in Healthy Volunteers
MycoMedica Life Sciences PBC
Healthy Volunteer
Completed·N/A·psilocybin
Evaluation of the Effect of a Single Dose of Psilocybin on Neural Correlates of Cognitive Control in Patients With Psychogenic Nonepileptic Seizures
Centre Hospitalier Universitaire de Nīmes
Psychogenic Nonepileptic SeizuresPsilocybin
Completed·Phase 1·psilocybin
A Second Psilocybin Group Therapy for the Treatment of Cancer-Related Anxiety in Partial Responders With Metastatic Cancer
University of Washington
Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·N/A·psilocybin
Effect of Psilocybin on the Positive Valence System in Treatment-resistant Depression
Centre Hospitalier Universitaire de Nīmes
Depressive DisorderDepressive Disorder, Treatment-ResistantHallucinogens+1 more
Completed·N/A·psilocybin
Low-Income Group Psilocybin Assisted Therapy for Depression
Matthew Hicks
Depression
Completed·N/A·psilocybin
Psilocybin in Alcohol Use Disorder With Comorbid Depression
Centre Hospitalier Universitaire de Nīmes
Alcohol-Related DisordersDepressive DisorderAddiction
Completed·Phase 1·psilocybin
Consciousness, Psilocybin, and Well-Being
University of Wisconsin, Madison
HealthyPsychedelic ExperiencesSleep
Completed·Phase 2·psilocybin
Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder
University of Chicago
Borderline Personality DisorderMajor Depressive Disorder
Completed·Phase 1·psilocybin
Does Serotonin System Stimulation Increase Pro-social Behavior? - A Comparative Pharmacological Neuroscientific Study in Healthy Humans
University of Zurich
Healthy
Completed·Phase 2·psilocybin
Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With Fibromyalgia
Kevin Boehnke
Fibromyalgia
Completed·Phase 2·psilocybin
Psilocybin-assisted Therapy for Treatment of Alcohol Use Disorder
Anders Fink-Jensen, MD, DMSci
Alcohol Use Disorder
Completed·Phase 1·psilocybin
Acute Effects of 2C-B Compared With MDMA and Psilocybin in Healthy Subjects
University Hospital, Basel, Switzerland
Healthy
Completed·Phase 2·psilocybin
Microdosing Psychedelics to Improve Mood
Rotem Petranker
Major Depressive Disorder
Completed·Phase 1·psilocybin
Psilocybin-Assisted Therapy for the Treatment of Cancer-Related Anxiety in Patients With Metastatic Cancer
University of Washington
Hematopoietic and Lymphatic System NeoplasmMetastatic Malignant Solid Neoplasm
Completed·Phase 1·psilocybin
Psilocybin-assisted CBT for Depression
University of California, Los Angeles
Major Depressive Disorder
Completed·Phase 1·psilocybin
PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout
University of Utah
DepressionBurnout, Professional
Completed·N/A·psilocybin
Psilocybin in Adults With and Without Autism Spectrum Disorder
King's College London
Autism Spectrum Disorder
Completed·Phase 1·psilocybin
Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain
Emory University
Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Completed·Phase 1·psilocybin
PsilOCD: A Pharmacological-Challenge Feasibility Study
Imperial College London
Obsessive-Compulsive Disorder
Completed·Phase 2·psilocybin
Efficacy and Safety of COMP360 Psilocybin Therapy in Anorexia Nervosa: a Proof-of-concept Study
COMPASS Pathways
Anorexia Nervosa
Completed·Phase 1·psilocybin
Psilocybin-assisted Therapy for Phantom Limb Pain
University of California, San Diego
Phantom Limb Pain
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View all conditions →How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.