24 Recruiting Now
Psychedelic Clinical Trials
Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.
Showing 100 of 271 trials
Recruiting·Phase 1·psilocybin
Psilocybin-assisted Treatment for Cannabis Use Disorder
Johns Hopkins University
Cannabis Use Disorder
Active, Not Recruiting·Phase 2·psilocybin
An Open Label Study of the Safety and Efficacy of Psilocybin in Participants With Treatment-Resistant Depression (P-TRD)
Sheppard Pratt Health System
Treatment Resistant Depression
Unknown·Phase 2·psilocybin
Evaluation of Psilocybin-Assisted Psychotherapy in Treating Severe Depression in Patients With PTSD
Apex Labs Ltd.
Post-traumatic Stress DisorderDepression
Enrolling by Invitation·Phase 1·psilocybin
PRoMiSS: Psilocybin and the Role of Music in Set and Setting
Johns Hopkins University
PsilocybinMusic Intervention
Recruiting·Phase 1·psilocybin
Digital Intervention for Psychedelic Preparation (DIPP): Comparing Meditation and Music-Based Programs
University College, London
Healthy
Completed·Phase 1·psilocybin
Psilocybin-assisted CBT for Depression
University of California, Los Angeles
Major Depressive Disorder
Recruiting·Phase 2·psilocybin
Does Psilocybin Require Psychedelic Effects to Treat Depression?
Centre for Addiction and Mental Health
Treatment-resistant Depression
Withdrawn·Phase 1·psilocybin
Bioavailability Study of Psilocybin in Normal Adults
University of Wisconsin, Madison
Healthy
Recruiting·Phase 2·psilocybin
Psilocybin in the Treatment of Cannabis Use Disorder: A-Proof-of-Concept Study
McMaster University
Cannabis Use Disorder, ModerateCannabis Use Disorder, Severe
Unknown·Early Phase 1·psilocybin
A Community of Practice Program With Psilocybin-assisted Therapy for End-of-Life Patients
The Roots to Thrive Society for Psychedelic Therapy
End of Life
Completed·Phase 2·psilocybin
Safety and Efficacy of Psilocybin for Body Dysmorphic Disorder
New York State Psychiatric Institute
Body Dysmorphic Disorders
Active, Not Recruiting·Phase 3·psilocybin
Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Recruiting·Phase 1·psilocybin
Study of Psilocybin Assisted Psychotherapy to Address Fear of Recurrence
University of Colorado, Denver
Breast CancerOvarian Cancer
Recruiting·Phase 2·psilocybin
Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN
Unity Health Toronto
Chronic Neuropathic PainPain Management
Not Yet Recruiting·Phase 2·psilocybin
NeuroGuard: Psilocybin Trial for Preventing Chemo-induced Neuropathy
M.D. Anderson Cancer Center
PsilocybinNeuropathy
Recruiting·Phase 1·psilocybin
The Neurobiological Effect of 5-HT2AR Modulation
Gitte Moos Knudsen
Basic Science
Unknown·N/A·psilocybin
Psilocybin in Patients With Fibromyalgia: EEG-measured Brain Biomarkers of Action
Imperial College London
Fibromyalgia
Completed·Phase 2·psilocybin
Psychopharmacology of Psilocybin in Cancer Patients
Johns Hopkins University
Depressive SymptomsAnxietyCancer
Recruiting·Phase 1·psilocybin
Investigating the Mechanisms of the Effects of Psilocybin on Visual Perception and Visual Representations in the Brain
University of California, Berkeley
Perception Disorders
Recruiting·Early Phase 1·psilocybin
Exploratory Study of Low Dose Psilocybin
University of Alabama at Birmingham
Demoralization
Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Therapy for Intergenerational Trauma
Rachel Yehuda
Psychological StressDepressionAnxiety
Terminated·Phase 1·psilocybin
Phase 1b Study in Patients With Short-Lasting Unilateral Neuralgiform Headache Attacks (SUNHA)
Beckley Psytech Limited
Short Lasting Unilateral Neuralgiform Headache Attacks
Completed·N/A·psilocybin
Low-Income Group Psilocybin Assisted Therapy for Depression
Matthew Hicks
Depression
Active, Not Recruiting·Phase 1·psilocybin
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Yale University
Major Depressive Disorder
Completed·Phase 1·psilocybin
Comparative Acute Effects of LSD, Psilocybin and Mescaline
University Hospital, Basel, Switzerland
Healthy
Completed·N/A·psilocybin
Psilocybin-facilitated Smoking Cessation Treatment: A Pilot Study
Johns Hopkins University
Nicotine Dependence
Recruiting·Phase 2·psilocybin
Investigation to Understand and Optimize Psilocybin
Charles Raison
Depression
Completed·Phase 2·psilocybin
Effects and Therapeutic Potential of Psilocybin in Alcohol Dependence
University of New Mexico
Alcohol Dependence
Recruiting·Phase 3·psilocybin
"A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder"
Cybin IRL Limited
Major Depressive Disorder
Completed·Phase 1·psilocybin
PAPR: PAP + MBSR for Front-line Healthcare Provider COVID-19 Related Burnout
University of Utah
DepressionBurnout, Professional
Recruiting·Phase 2·psilocybin
Does Psilocybin Change Synaptic Density in Amnestic Mild Cognitive Impairment
Centre for Addiction and Mental Health
Amnestic Mild Cognitive Impairment
Completed·N/A·psilocybin
Psilocybin in Adults With and Without Autism Spectrum Disorder
King's College London
Autism Spectrum Disorder
Completed·Phase 1·psilocybin
Psilocybin and Spiritual Practice
Johns Hopkins University
Healthy
Recruiting·Phase 3·psilocybin
A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder
Cybin IRL Limited
Major Depressive Disorder (MDD)Depression in AdultsDepression - Major Depressive Disorder+3 more
Completed·Phase 2·psilocybin
Open-label Study to Assess the Safety and Efficacy of Psilocybin With Psychotherapy in Adult Participants With Fibromyalgia
Kevin Boehnke
Fibromyalgia
Unknown·N/A·Other
Personality and Drug Use
Psychedelic Data Society
No Conditions Study Focus on Substance Use and Personality
Not Yet Recruiting·Phase 2·psilocybin
Effects of Psilocybin on Speech Fluency, Struggle, and Brain Activity in People Who Stutter
NYU Langone Health
Stuttering
Unknown·Phase 2·psilocybin
Investigating the Therapeutic Effects of Psilocybin in Treatment-Resistant Post-Traumatic Stress Disorder
Halucenex Life Sciences Inc.
Treatment Resistant DisordersPost Traumatic Stress Disorder
Not Yet Recruiting·Phase 2·psilocybin
Mindfulness-based Psilocybin Therapy for PTSD
Anthony P King
Post Traumatic Stress DisorderDepression - Major Depressive Disorder
Enrolling by Invitation·N/A·psilocybin
The Role of Personal Experience for the Therapeutic Attitude in the Context of Substance-assisted Therapy Training
Felix Mueller
Personal Experience of Substance-assisted Therapy Using Psilocybin, MDMA, and LSD
Enrolling by Invitation·N/A·psilocybin
Salivary Oxytocin as a Biomarker of Psychedelic Treatment
University of Geneva, Switzerland
Major Depressive Disorder (MDD)
Terminated·N/A·psilocybin
PSIL201 Long-term Follow-up Study: Psilocybin or Niacin / Major Depressive Disorder
Usona Institute
Major Depressive Disorder
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin for Treatment-Resistant Depression
University of Colorado, Denver
Major Depressive DisorderAnhedoniaTreatment Resistant Depression
Recruiting·Phase 2·psilocybin
Psilocybin or Ketamine for Alcohol Use Disorder: An Active Comparator Trial
University of Iowa
Alcohol Use DisorderAlcohol DependenceAlcohol Abuse
Completed·Phase 2·psilocybin
Effects of Psilocybin in Major Depressive Disorder
Johns Hopkins University
Major Depressive Disorder
Completed·Phase 2·psilocybin
The Safety and Efficacy Of Psilocybin as an Adjunctive Therapy in Participants With Treatment Resistant Depression
COMPASS Pathways
Treatment Resistant Depression
Active, Not Recruiting·Phase 1·psilocybin
ELE-101 Safety & Tolerability Study in Healthy Participants and Patients With Depression
Eleusis Therapeutics
Healthy VolunteersMajor Depressive DisorderDepression
Completed·Phase 1·psilocybin
Repeat Dosing of Psilocybin in Migraine Headache
Yale University
Migraine Headache
Completed·Phase 2·psilocybin
Psilocybin vs Escitalopram for Major Depressive Disorder: Comparative Mechanisms
Imperial College London
Depressive Disorder, Major
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy
M.D. Anderson Cancer Center
Depression, AnxietyPsilocybin-Assisted PsychotherapyAdvanced Cancer
Recruiting·Phase 2·psilocybin
Treatment With Psilocybin for Chronic Neuropathic Pain and Depression (TRANSCEND)
Centre for Addiction and Mental Health
Treatment Resistant DepressionChronic Pain
Completed·Phase 1·psilocybin
The Effects of Psilocybin-Facilitated Experience on the Psychology and Effectiveness of Religious Professionals
NYU Langone Health
Religious or Spiritual Problem
Recruiting·Phase 1·psilocybin
Acute Effects of MDMA Co-administration on the Response to Psilocybin in Healthy Subjects
University Hospital, Basel, Switzerland
Healthy
Completed·Early Phase 1·psilocybin
Precision Functional Brain Mapping in Psilocybin
Washington University School of Medicine
Psilocybin
Completed·Phase 2·psilocybin
Microdosing Psychedelics to Improve Mood
Rotem Petranker
Major Depressive Disorder
Enrolling by Invitation·Phase 1·psilocybin
Psilocybin With Intracranial Neural Sensing
Joshua Woolley, MD, PhD
Chronic Pain
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin for Treatment of OCD-2
Francisco A Moreno
Obsessive - Compulsive Disorder
Unknown·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Cancer Patients With Major Depressive Disorder
Maryland Oncology Hematology, PA
Major Depressive Disorder
Recruiting·Phase 2·psilocybin
Psilocybin-assisted Existential, Attachment and RelationaL (PEARL) Therapy for Patients With Advanced Cancer
University Health Network, Toronto
Advanced CancerStage IV Solid Tumor CancerStage IV Sarcoma of Bone+3 more
Completed·Phase 1·psilocybin
Psilocybin as a Treatment for Anorexia Nervosa: A Pilot Study
Imperial College London
Anorexia Nervosa
Recruiting·Phase 2·psilocybin
Psilocybin With Pimavanserin Compared to Psilocybin Alone for the Treatment of Major Depressive Disorder
Icahn School of Medicine at Mount Sinai
Major Depressive Disorder
Recruiting·Phase 2·psilocybin
Psilocybin for Opioid Use Disorder (OUD)
NYU Langone Health
Opioid Use Disorder
Active, Not Recruiting·Phase 1·psilocybin
Comparing the Effects of Psilocin and Psilocybin in Healthy Adults
University of California, San Francisco
Healthy
Withdrawn·Phase 2·psilocybin
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDD
Massachusetts General Hospital
Treatment-Resistant Major Depressive Disorder
Recruiting·Phase 1·psilocybin
Effects of Psilocybin on Electrophysiology and the Dynamic Content of Thought
Johns Hopkins University
Healthy
Not Yet Recruiting·Phase 3·psilocybin
Psilocybin Intervention for Veterans Overcoming Treatment-Resistant Depression
VA Office of Research and Development
Major Depression
Completed·Phase 2·psilocybin
The Effect of Psilocybin on MDD Symptom Severity and Synaptic Density
Section for Affective Disorders; Northern Stockholm Psychiatry
Major Depressive DisorderDepression
Recruiting·Phase 1·psilocybin
The RECAP2 Study: Midazolam and Psilocybin
University of Wisconsin, Madison
Psilocybin
Recruiting·Phase 2·psilocybin
Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality
The University of Texas Health Science Center, Houston
Bipolar II DisorderDepression, BipolarSuicidality
Completed·N/A·Other
Characterization of Altered Waking States of Consciousness in Healthy Humans
University of Zurich
Altered Waking States of Consciousness in Healthy Humans
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin as a Treatment for Chronic Pain in Smokers
Yale University
Smokers With Chronic Pain
Recruiting·Phase 1·psilocybin
Feasibility, Clinical Effects, and Safety of Psilocybin-assisted Psychotherapy for Treatment-resistant OCD
Centre for Addiction and Mental Health
Obsessive-Compulsive Disorder
Not Yet Recruiting·Phase 1·psilocybin
Psilocybin for Chronic Pelvic Pain (CPP) in Women: A Pilot Feasibility Study
Oregon Health and Science University
Chronic Pelvic Pain
Completed·Phase 1·psilocybin
Psilocybin Combined With Multidisciplinary Palliative Care in Demoralized Cancer Survivors With Chronic Pain
Emory University
Hematopoietic and Lymphoid Cell NeoplasmMalignant Solid Neoplasm
Completed·Phase 1·psilocybin
Consciousness, Psilocybin, and Well-Being
University of Wisconsin, Madison
HealthyPsychedelic ExperiencesSleep
Recruiting·Phase 1·psilocybin
Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability
Johns Hopkins University
StrokeChronic StrokeIntracerebral Haemorrhage+9 more
Completed·Phase 2·psilocybin
A Study of Psilocybin for Major Depressive Disorder (MDD)
Usona Institute
Depressive Disorder, Major
Terminated·Phase 1·psilocybin
Effects of Psilocybin in Concussion Headache
Yale University
Post-Traumatic Headache
Completed·Phase 1·psilocybin
Effects of SERT Inhibition on the Subjective Response to Psilocybin in Healthy Subjects
University Hospital, Basel, Switzerland
Healthy
Recruiting·Phase 1·psilocybin
Psilocybin and Methylenedioxymethamphetamine (MDMA) for Post-traumatic Stress Disorder (PTSD)
Johns Hopkins University
Posttraumatic Stress Disorder
Recruiting·N/A·psilocybin
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
Yale University
OCDMajor Depressive Disorder (MDD)Alcohol Use Disorder (AUD)+8 more
Recruiting·Phase 3·psilocybin
Psilocybin-Assisted Therapy in Treatment-Resistant Depression
University of North Carolina, Chapel Hill
Refractory DepressionTreatment Resistant Depression
Recruiting·Phase 2·psilocybin
Standardized Natural Psilocybin-assisted Psychotherapy for Tapering of Opioid Medication
University of British Columbia
Opioid DependenceChronic Pain
Completed·Phase 1·psilocybin
Pilot RECAP Study in Healthy Volunteers
University of Wisconsin, Madison
Psychedelic ExperiencesAmnesia
Recruiting·Phase 2·psilocybin
Psilocybin for Hospitalized Patients with Treatment-resistant Depression
University Hospital, Ghent
Treatment Resistant Depression
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin With Psychotherapy for Improving Chronic Pain in Cancer Patients Requiring Opioids
Roswell Park Cancer Institute
Hematopoietic and Lymphatic System NeoplasmMalignant Solid Neoplasm
Active, Not Recruiting·Phase 2·psilocybin
Psilocybin Treatment of Major Depressive Disorder With Co-occurring Alcohol Use Disorder
Johns Hopkins University
Major Depressive DisorderAlcohol Use Disorder
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Cognitive Processing Therapy for Chronic PTSD
Unity Health Toronto
Post Traumatic Stress DisorderPTSDChronic PTSD
Completed·Phase 3·psilocybin
Frontline Clinician Psilocybin Study
University of Washington
Burnout, CaregiverBurnout, ProfessionalCOVID-19+3 more
Completed·Phase 2·psilocybin
The Safety and Efficacy of Psilocybin in Patients With Treatment-resistant Depression and Chronic Suicidal Ideation
Sheppard Pratt Health System
Treatment Resistant DepressionSuicidal Ideation
Completed·N/A·psilocybin
Psilocybin-assisted Interpersonal Therapy for Depression
University of Otago
Depressive Disorder, Treatment-Resistant
Not Yet Recruiting·Phase 2·psilocybin
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
Yale University
Chronic Low Back Pain (CLBP)Physical TherapyPsilocybin
Not Yet Recruiting·Early Phase 1·psilocybin
Psilocybin-Assisted Psychotherapy in Treating Irritable Bowel Syndrome (IBS)
NYU Langone Health
IBS - Irritable Bowel Syndrome
Not Yet Recruiting·Phase 1·psilocybin
The Acute Effects of Psilocybin on Cognition, Memory, and Brain Function
Manoj Doss
Healthy
Recruiting·Phase 2·psilocybin
Psilocybin on Brain Mechanisms of Motivation in OUD
Anna Rose Childress, Ph.D.
Opioid Use Disorder
Completed·Phase 2·psilocybin
Psilocybin-facilitated Treatment for Cocaine Use
University of Alabama at Birmingham
Cocaine-Related Disorders
Recruiting·Phase 1·psilocybin
The ENHANCE Study: taVNS and Psilocybin
University of Wisconsin, Madison
HealthyPsychedelic ExperiencesVagus Nerve Stimulation
Recruiting·Early Phase 1·psilocybin
Safety Profile of Psilocybin for Cocaine Use Disorder
University of California, Los Angeles
Cocaine Use Disorder
Recruiting·Phase 1·psilocybin
Psilocybin Therapy for Chronic Low Back Pain
Joshua Woolley, MD, PhD
Chronic Low-back Pain
Recruiting·Phase 1·psilocybin
Psilocybin-Assisted Therapy for Physician Well-Being and Burnout
University of California, San Diego
BurnoutBurnout, Healthcare Workers
More trials available. Refine your search to see specific results.
How to Join a Clinical Trial
Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.
1. Review
Read the trial details, eligibility criteria, and what participation involves.
2. Contact
Reach out to the study team using the contact information provided.
3. Screen
Complete the screening process to determine if you're eligible.