Comparison of Two Magnesium Sulfate Protocols in Opioid-Free Anesthesia for Bariatric Surgery
Sponsored by Hospital HM Nou Delfos
About This Study
This retrospective observational study aims to compare postoperative morphine consumption in patients undergoing bariatric surgery with opioid-free anesthesia (OFA) using two different intravenous magnesium sulfate administration protocols: a single bolus versus a bolus followed by continuous infusion. Medical records of 110 patients operated between June 2022 and December 2023 at Hospital HM Nou Delfos were reviewed. All patients received standardized OFA, and only the magnesium protocol varied between the groups. The primary objective was to evaluate total morphine consumption during the first 48 hours postoperatively. Secondary outcomes included pain scores, antiemetic use, and adverse events. This study was approved by the hospital's Research Ethics Committee (Protocol V3\_12.05.2025).
Conditions Studied
Eligibility
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Inclusion Criteria: Age between 18 and 65 years Body mass index (BMI) ≥ 30 kg/m² ASA physical status II or III Underwent laparoscopic bariatric surgery (sleeve gastrectomy or Roux-en-Y gastric bypass) under opioid-free total intravenous anesthesia Exclusion Criteria: Pregnancy or breastfeeding Chronic opioid use before surgery Known allergy to magnesium sulfate or any drug used in the anesthetic protocol Severe renal or hepatic insufficiency Untreated coagulopathy Active substance abuse Uncontrolled psychiatric disorders Intraoperative complications requiring deviation from the protocol Postoperative morphine consumption exceeding institutional standards