WithdrawnPhase 2ibogaine

Trifecta Research Study

NCT ID

NCT06810765

Start Date

2025-09

Est. Completion

2027-12

About This Study

The Special Operations Care-Fund (SOC-F) will sponsor the application of four treatments - hormone replacement, magnetic resonance brain stimulation, ibogaine, and 5-Meo-DMT - to Special Operations Forces veterans with a history of combat deployments, traumatic brain injury, and problems with mental health and cognitive functioning. An observational study will be conducted in parallel by the Johns Hopkins Center for Psychedelic and Consciousness Research to determine the effectiveness and safety of each treatment, primarily through measuring post-treatment changes in PTSD symptoms and cognitive functioning.

Conditions Studied

PTSD - Post Traumatic Stress DisorderCognitive DysfunctionBrain TraumaBrain Injuries

Interventions

•Hormone Replacement Therapy (HRT)
•Magnetic Resonance Therapy (MeRT)
•ibogaine with magnesium treatment
•5-MeO-DMT

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* At least 18 years of age
* Sponsored by SOC-F Program

Exclusion Criteria:

* Diagnosis of Schizophrenia, Bipolar I or II disorder for which patient has been hospitalized or medicated, Depersonalization and/or Derealization Disorder
* Cerebellar dysfunction, Epilepsy, Psychosis or acute confusional state, Dementia
* Prolonged corrected QT interval (QTc) Interval (450ms in males; 470ms in females)
* History of heart failure or hypertrophic heart
* Active blood clots (e.g., Pulmonary embolism, Deep vein thrombosis)
* Major respiratory conditions (e.g., Emphysema, Cystic fibrosis)
* Severe chronic gastrointestinal issues (e.g., bleeding ulcer, leaky gut syndrome)
* Within 6 months of surgeries
* Abnormal blood test results (e.g., potassium or magnesium outside normal range)
* Impaired kidney or liver function
* Refusal to taper off of selective serotonin reuptake inhibitor (SSRI) medication

Study Locations (1)

Johns Hopkins Center for Psychedelic and Consciousness Research