Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion

About This Study

Postoperative depression is a perioperative psychological complication that severely affects patient recovery and quality of life. In extreme cases, it may lead to suicidal behavior. Postoperative depression can be seen in various surgical operations . High rates of anxiety and depression have been reported in cohorts of patients with IIH, though it is not clear whether there is any direct relationship. Worse outcomes in terms of disability level and symptom resolution have been observed in IIH patients who have a known co-existing psychiatric illness compared to those who do not .

Conditions Studied

Interventions

• •normal Saline
• •Ketamine

Eligibility

Inclusion Criteria:

* patients of both sex
* with an age range from 20 to 44 years old
* having moderate to severe depressive symptoms
* an expected hospital stay of no less than 7 days

Exclusion Criteria:

* history of epilepsy
* major depressive disorder patients
* drug abuse
* history of allergy to the research drug
* heart rate \> 120 beats per minute
* systolic blood pressure \> 180 mmHg
* heart failure
* renal or liver dysfunction
* patients who cannot cooperate to complete psychiatric assessments
* pregnant or breast-feeding women
* patients who refuse to sign informed consent.

Study Locations (1)