Open-Label Dose-Ranging Study of Oral SM-001 in Healthy Adults

Inclusion Criteria:

* Healthy adults: men and women ages 25-65 years of age
* Previous experience with a psychedelic drug
* Vital Signs within normal limits for temperature (oral), respiratory rate, heart rate
* Normal blood pressure (for age) in the absence of antihypertensive drugs
* Normal complete blood count and differential, platelets, coagulation ((PT/PTT)
* Liver function tests ≤ 1.5X upper limits of normal
* Renal function (BUN, serum Creatinine) - within normal limits
* Able to understand and willing to comply with Study Protocol requirements.
* Willing to abstain from alcohol for at least 72 hours prior to and following Study Day 0
* No use of recreational drugs for at least 14 days prior to Study Day 0.
* Women who are not pregnant or lactating.

Exclusion Criteria (None can apply):

* Body Mass Index \> 30 or \< 20
* Systemic condition that includes, but is not limited to: hematological, immunological, hepatic, renal, cardiac, neurological conditions that is under current treatment or causes abnormal physical or laboratory parameters.
* History of seizures
* History of drug or alcohol abuse
* History of psychiatric disorder or history of significant trauma, as defined by DSM- V.
* Use of SSRIs, MAO inhibitors, or other psychoactive compounds either pharmaceutical drugs or botanical in origin (i.e., 5-HTP, St John's Wort)
* Any condition which, in the opinion of the Investigators, would preclude the use of the test article or the successful completion of the study.