UnknownN/Aketamine

Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort

Sponsored by Stella Center

NCT ID
NCT05855876
Target Enrollment
20 participants
Start Date
2023-07-05
Est. Completion
2024-04-05

About This Study

The purpose of this study is to examine measures of GrimAge clock in SOF members undergoing treatment for PTSD/TBI using CSB.

Conditions Studied

Post-Traumatic Stress DisorderTraumatic Brain Injury

Interventions

  • subanesthetic ketamine infusions and bilateral cervical sympathetic blocks

Eligibility

Age:40 Years - 60 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria:

* Recruited from SOF with an active duty history of at least 5 years.
* Subjects may be in active duty or retired, male and female, between the ages of 40 and 60 years old.
* The participants must have a confirmed diagnosis of PTSD, identified by Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores higher than 40.
* The participants must have been on a stable pharmacological or psychotherapeutic therapy for at least three months (if applicable), and continue this treatment throughout the duration of the study.
* They must be able and willing to consent for the study. Individuals who are able to become pregnant must adhere to a medically accepted method of contraception (eg. hormonal birth control, barrier birth control, intrauterine device, abstinence).

Exclusion Criteria:

* Existing Horner syndrome;
* Allergy to local anesthetics or contrast;
* Previous history of stellate ganglion block with psychosis;
* Admission to in-patient psychiatric facility within last 3 months;
* History of moderate of severe TBI;
* Currently pregnant or breastfeeding;
* Current substance use disorder, or test positive for 1 or more illegal or controlled drugs on the initial urine drug screen, such as cocaine, marijuana, amphetamines, opioids, benzodiazepines, amongst others;
* Previous behavioral health diagnoses (bipolar I, psychosis, etc);
* Currently undergoing exposure therapy.

Study Locations (1)

Stella Center
Westmont, Illinois, United States

This trial is not recruiting

This study is currently not accepting new participants.

Find recruiting trials
Data Source
ClinicalTrials.gov

Last updated from source

Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort | Huxley