UnknownN/Aketamine

Opioid Sparing Anesthesia in Lumbar Spine Surgery

NCT ID

NCT05594407

Target Enrollment

60 participants

Start Date

2022-08-01

Est. Completion

2024-08-01

About This Study

The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus remifentanil analgesia in lumbar spine surgery

Conditions Studied

Pain, PostoperativePain, AcutePain, ChronicPain, NociceptiveKetamineLidocaineDexmedetomidineAnalgesiaAnalgesicsLumbar Spine Surgery

Interventions

•dexmedetomidine-ketamine-lidocaine
•Remifentanil

Eligibility

Age:18 Years - 75 Years

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* Adult patents
* American Society of Anesthesiologists (ASA) class I-III
* elective spine surgery

Exclusion Criteria:

* body mass index (BMI) \>35 kg/m2
* contraindications to local anesthetic administration
* systematic use of analgesic agents preoperatively
* chronic pain syndromes preoperatively
* neurological or psychiatric disease on treatment
* pregnancy
* severe hepatic or renal disease
* history of cardiovascular diseases/ arrhythmias/ conduction abnormalities
* bradycardia(\<55 beats/minute)
* drug or alcohol abuse
* language or communication barriers lack of informed consent

Study Locations (1)

Evangelismos General Hospital

Athens, Greece