CompletedN/AOther

Nociception Level During Opioid-sparing Anaesthesia Versus Conventional Opioid-based Anaesthesia

NCT ID

NCT05485480

Target Enrollment

70 participants

Start Date

2022-11-17

Est. Completion

2024-02-08

About This Study

The aim of this double blind, randomised controlled non-inferiority trial is to compare the antinociceptive efficiency of an opioid-sparing and a conventional opioid-based anaesthesia protocol with the help of the CEcertificated Pain Monitoring Device (PMD-200).

Conditions Studied

Analgesia

Interventions

•conventional opioid-based group
•opioid-sparing group

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Informed Consent as documented by signature
* Age older than 18 years
* Ability to give informed consent
* Undergoing scheduled general surgical, gynaecological or urological laparoscopic surgery
* American Society of Anesthesiology Score (ASA) status I, II, III

Exclusion Criteria:

* Inability to give informed consent
* ASA status IV and V
* Pregnant or breastfeeding women
* Allergy to one of the study drugs
* Urgent surgery
* Surgery with planned regional anaesthesia
* Outpatient surgery
* Atrioventricular block, intraventricular or sinoatrial block
* Atrial fibrillation
* Sinus bradycardia
* Cardiac insufficiency with a reduced left ventricular ejection fraction of below 40%
* Coronary artery disease
* Epilepsy
* Liver cirrhosis
* Chronic kidney disease (Clearance \< 50ml/h)
* Chronic opioid therapy
* Chronic pain

Study Locations (1)

Department of Anaesthesiology, University Hospital Basel

Basel, Switzerland