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Opioid-free Anesthesia in Thyroidectomies

NCT ID

NCT05243940

Target Enrollment

60 participants

Start Date

2022-03-07

Est. Completion

2024-02-01

About This Study

The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies. Recovery parameters and nociception levels throughout the operation will be evaluated

Conditions Studied

Pain, Post OperativePain, AcutePain, ChronicPain, NeuropathicPain, NociceptiveKetamineDexmedetomidineLidocaineFentanylAnalgesiaAnalgesicsAnalgesics Non-narcotic

Interventions

•dexmedetomidine-ketamine-lidocaine (DKL)
•remifentanil infusion

Eligibility

Age:25 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* adult patients
* American Society of Anesthesiologists (ASA) classification I-II
* elective thyroidectomy

Exclusion Criteria:

* body mass index (BMI) \>35 kg/m2
* contraindications to local anesthetic administration
* systematic use of analgesic agents preoperatively
* chronic pain syndromes preoperatively
* neurological or psychiatric disease on treatment
* pregnancy
* severe hepatic or renal disease
* history of cardiovascular diseases/ arrhythmias/ conduction abnormalities
* bradycardia(\<55 beats/minute)
* drug or alcohol abuse
* language or communication barriers lack of informed consent

Study Locations (1)

General Hospital of Athens, "Georgios Gennimatas"