Opioid-free Anesthesia and Acute Postoperative Pain

About This Study

Control of intraoperative and postoperative pain with the use of opioids constitutes normal practice. Opioid free anesthesia (OFA) is a relatively recent anesthesiology practice according to which opioids are not administered during surgery and are avoided postoperatively. Opioid free anesthesia seems to provide better quality of postoperative analgesia while protecting the patient from the side effects of opioids such as respiratory depression, postoperative nausea and vomiting (PONV), opioid induced hyperalgesia and postoperative cognitive dysfunction. The aim of this study is to investigate the possible difference in the intensity of postoperative pain (based on the numeric rating scale 0-10) and the presence of PONV in patients undergoing transurethral urologic surgery under general anesthesia, when patients receive randomly either opioid free anesthesia (OFA) or opioid based anesthesia (OBA).

Conditions Studied

Interventions

• •OFA
• •OBA

Eligibility

Inclusion Criteria:

* Patients aged\>18 years old
* ASA I-III
* Patients scheduled for elective transurethral urologic surgery with general anesthesia

Exclusion Criteria:

* • Patient refusal

  * Use of opioids pre-op
  * Inability to read or write
  * Known psychiatric disease under medication
  * Dementia
  * Severe liver and renal disease
  * Known allergy to drugs used
  * Known arrhythmia (2nd-3rd AV block, acute unstable angina, acute myocardial infarction in the past 6 weeks or severe cardiac problem-condition)
  * Heart rate\<45 bpm
  * Pre-op minimental test\<23
  * Major surgery complications (hemorrhage with need for transfusion)

Study Locations (1)