CompletedN/Aketamine

Esketamine on Postpartum Depression in Cesarean Section Women

NCT ID

NCT04860661

Target Enrollment

336 participants

Start Date

2021-05-01

Est. Completion

2024-03-31

About This Study

This study was to explore the preventive effect of esketamine on postpartum depression (PPD) in cesarean section, and to evaluate the safety of the drug

Conditions Studied

EsketaminePostpartum Depression

Interventions

•Esketamine
•Normal saline

Eligibility

Sex:FEMALE

Age:18 Years - 40 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Elective cesarean section;
* 18-40 years;
* Primipara;
* Singleton pregnancy;
* Sign informed consent.

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) grade III and above;
* Intracranial hypertension;
* Hypertension;
* Severe heart disease;
* Hyperthyroidism patients without treatment or insufficient treatment;
* Liver and kidney dysfunction;
* Preeclampsia or eclampsia;
* Mental disorder, mental retardation;
* Drug abuse and alcoholism;
* Contraindication of intraspinal anesthesia;
* The preoperative EPDS score ≥10;
* Participated in other clinical studies.

Study Locations (1)

Tongji Hospital