UnknownN/Aketamine

Morphine Versus Ketamine as Adjuvants in Paravertebral Blocks

NCT ID

NCT04852484

Target Enrollment

90 participants

Start Date

2021-04-16

Est. Completion

2024-04-16

About This Study

The aim of this study will be to compare the effects of morphine versus ketamine when they are used as adjuvants to the local anesthetic in paravertebral nerve blocks performed with the aid of ultrasound. Furthermore, a group of local anesthetic without an adjuvant, will also be compared to the two groups

Conditions Studied

Pain, PostoperativePain, AcutePain, ChronicPain, NeuropathicMorphineKetamineAnalgesia

Interventions

•local anesthetic-morphine
•local anesthetic-ketamine
•local anesthetic

Eligibility

Age:25 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* patients undergoing elective thoracotomy for any cause
* American Society of Anesthesiologists class I-III (ASA I-III)

Exclusion Criteria:

* known allergy to local anesthetic
* local inflammation
* paravertebral tumor
* severe respiratory distress ( breathing dependence on accessory muscles)
* severe spinal deformities
* severe ipsilateral diaphragmatic paresis
* morbid obesity (BMI\>35 kg/m2)
* blood coagulation disorders
* known contraindication for administration of ketamine or morphine
* psychiatric disorders
* severe cardiovascular disease
* systematic use of opioids due to chronic pain
* renal or hepatic failure
* patients who refuse to participate

Study Locations (2)

Aretaieion University Hospital

Athens, Greece

KAT General Hospital of Athens