UnknownN/Aketamine

Lidocaine and Magnesium and Ketamine in Gynecological Surgery

NCT ID

NCT04622904

Target Enrollment

90 participants

Start Date

2020-11-14

Est. Completion

2023-11

About This Study

The aim of this study will be to investigate the effect of a combination of intravenous infusions of lidocaine and magnesium versus a combination of intravenous infusions of lidocaine and ketamine versus an intravenous infusion of lidocaine alone on recovery profile, quality of recovery and postoperative pain after elective gynecological surgery

Conditions Studied

Pain, PostoperativePain, AcutePain, ChronicPain, NeuropathicLidocaineKetamineMagnesiumCentral Nervous System DepressantsAnalgesicsNeurotransmitter AgentsAnalgesics, Non-narcotic

Interventions

•lidocaine-magnesium infusion
•lidocaine-ketamine infusion
•lidocaine infusion

Eligibility

Sex:FEMALE

Age:25 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* adult female patients
* American Society of Anesthesiologists (ASA) classification I-II
* elective open gynecological surgery

Exclusion Criteria:

* body mass index (BMI) \>35 kg/m2
* contraindications to local anesthetic administration or non-steroidal agents administration
* systematic use of analgesic agents preoperatively
* chronic pain syndromes preoperatively
* neurological or psychiatric disease on treatment
* pregnancy
* severe hepatic or renal disease
* history of cardiovascular diseases/ arrhythmias/ conduction abnormalities
* drug or alcohol abuse
* language or communication barriers
* lack of informed consent

Study Locations (1)

Aretaieion University Hospital