UnknownN/ALSD

Effect of a Low Starch Diet in Patients With Ankylosing Spondylitis

NCT ID

NCT04386538

Target Enrollment

150 participants

Start Date

2022-01-03

Est. Completion

2022-12-30

About This Study

The aim of this study is to explore the effect of a low starch diet (reduction of at least 40%) in the gut bacteria modulation, especially Klebsiella pneumoniae, and its relation to disease activity, functional impairment and quality of life in patients with Ankylosing Spondylitis (AS).

Conditions Studied

SpondyloarthritisAnkylosing Spondylitis

Interventions

•Low Starch Diet (LSD)
•General healthy eating

Eligibility

Age:18 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Age between 18 and 75 years old
* Available to comply with study protocol
* Ability to read and sign the Informed Consent
* Diagnosis of Ankylosing Spondylitis performed by the rheumatologist, according to the ASAS classification criteria, revised in 2016
* Positive HLA-B27allele
* Stable dose therapy within 3 months before selection

Exclusion Criteria:

* Pregnant, breastfeeding or planning to become pregnant within the study period
* Prior or current clinical history of drug or other substances abuse
* Subjects with uncontrolled clinical conditions, like neoplastic diseases, renal failure, liver impairment, uncompensated cardiac disease
* Dietetic restrictions due to religious believes or others incompatible with the study protocol
* Impossibility to attend to the mandatory personal clinical evaluation
* Presence of pacemaker, making impossible to perform the impedance body composition analysis
* Change in therapy during the intervention period

Study Locations (1)

Instituto Português de Reumatologia