Dexmedetomidine-Ketamine Infusion in Breast Surgeries

About This Study

* This is a prospective randomized double blind controlled study. * Female patients undergoing radical mastectomy will be included in this study where they will be randomly allocated into; - Control group in which patients will receive continuous infusion of normal saline. Dexmedetomidine-Ketamine group in which patients will receive continuous infusion of ketamine and dexmedetomidine. The intraoperative and postoperative opioid consumption will be measured. Also, the postoperative pain score and the incidence of chronic pain will be assessed.

Conditions Studied

Interventions

• •Placebos
• •Dexmedetomidine +Ketamine

Eligibility

Inclusion Criteria:

* Female patients aged 50-70 years, ASA class I-III, and presented for elective radical mastectomy.

Exclusion Criteria:

* Patients refused to participate.
* Patients with known or suspected or known allergy to the used medication.
* Patients with preoperative chronic pain,
* Patients received preoperative opioids or gabapentoids.
* Patients with major cardiac, renal, respiratory, or hepatic disease.
* Uncooperative patients.
* Obese patients with BMI \>36

Study Locations (1)