CompletedEarly Phase 1ketamine

Single Bolus Dose of Ketodex Versus Ketofol For Prevention Of Emergence Agitation In Adults Undergoing Nasal Surgeries

NCT ID

NCT04018157

Target Enrollment

150 participants

Start Date

2019-07-03

Est. Completion

2019-11-23

About This Study

* emergence agitation is seen in around 68% after nasal surgeries. Agitated patients needs more staff and nurses to control their abnormal movement which leads to self extubation , removal of catheters and bruises in the extremities. * Dexmedetomidine, ketamine, propofol intravenous infusion and other agents was used to prevent EA . Recently, ketodex is found to reduce the incidence and severity of EA . * We aim to compare single bolus dose of Ketodex Versus Ketofol For Prevention Of emergence Agitation in adults undergoing nasal surgeries.

Conditions Studied

Agitation, Emergence

Interventions

•"Ketamine" and "dexmedetomidine" and "propofol" and "0.9%saline"

Eligibility

Age:21 Years - 60 Years

Healthy Volunteers:Yes

View full eligibility criteria

Inclusion Criteria:

* Patient acceptance.

  * Both gender.
  * Age (21-60) years old.
  * patient with Body Mass Index (BMI) (25-35kg/m²).
  * American Society of Anesthesiologist (ASA) I / II
  * Adult patient scheduled to elective nasal surgeries

Exclusion Criteria:

* \- Patient with difficult airway (mallampati III,IV).
* Altered mental status (psychiatric and anxiety disorder).
* Post traumatic stress disorders.
* History of allergy to study drugs.
* Patient on sedative or hypnotic medication.
* Patients with chronic pain or on painkiller.
* Patients with severe hepatic or kidney impairment.
* Patients having a history of thyrotoxicosis, hypertension, cardiac , chest or neurological disease.
* Patient receiving B agonist.
* Pregnant or breast feeding female.

Study Locations (1)

Faculty of Medicine