TerminatedPhase 4Other

Avoiding Neuromuscular Blockers to Reduce Complications

NCT ID

NCT03962725

Target Enrollment

3 participants

Start Date

2019-08-07

Est. Completion

2022-12-19

About This Study

The goal of this study to evaluate whether eliminating the use of non-depolarizing neuromuscular blocking agents (NMBA) for maintenance of general anesthesia reduces postoperative pulmonary complications in higher risk patients.

Conditions Studied

Respiratory FailureRespiratory InfectionAspiration PneumoniaPneumonitisAtelectasisBronchospasm

Interventions

•Neuromuscular Blocking Agents
•Anesthetic Adjuncts

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* At least 18 years of age
* Undergoing non-cardiac surgery under general anesthesia with an endotracheal tube
* those at higher risk of developing postoperative pulmonary complications (internally validated risk prediction score of \>=20)

Exclusion Criteria:

* Emergency surgery
* Ambulatory (outpatient) surgery
* Scheduled for elective postoperative ventilation
* Planned return to operating room within 7 days of index procedure
* Exposure to general anesthesia within 7 days prior to planned procedure
* Requirement mechanical ventilation at baseline (not including stable use of CPAP/BiPAP)
* Pregnant patients: as detected by patient self-reporting or diagnosed by preoperative pregnancy testing according to institutional policies at BIDMC and MGH
* Allergy to either non-depolarizing muscle relaxants or sugammadex
* Clinician refusal
* Prisoner

Study Locations (2)

Massachusetts General Hospital

Boston, Massachusetts, United States

Beth Israel Deaconess Medical Center