UnknownN/Aketamine
Post-op Ketamine Study
Sponsored by Rothman Institute Orthopaedics
NCT ID
NCT03865550
Target Enrollment
75 participants
Start Date
2016-03-28
Est. Completion
2019-04-27
About This Study
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.
Conditions Studied
Interventions
- •Isotonic saline
- •Ketamine Injectable Solution
Eligibility
View full eligibility criteria
Inclusion Criteria: * 18 - 85 years of age * ASA I - IV * Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia Exclusion Criteria: * BMI over 40\* * Contraindication or allergy to opioid pain medication or ketamine\* * Daily opioid use for pain control before surgery in excess of systemic morphine equivalent to 10 mg\* * Ejection fraction (EF) less than 30% * Creatinine clearance less than 30 mL/min\* * History of chronic liver failure * Desire for nerve block or general anesthesia * Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic stress disorder, schizophrenia) * Prior surgery on ipsilateral knee within the last 6 months * Alcohol abuse
Study Locations (1)
Rothman Institute
Philadelphia, Pennsylvania, United States