CompletedN/Aketamine

Pharmacokinetics of Antiepileptics in Patients on CRRT

NCT ID

NCT03632915

Target Enrollment

18 participants

Start Date

2017-11-20

Est. Completion

2019-12-31

About This Study

The purpose of the study is to measure levels of any of the following AEDs (levetiracetam, phenobarbital, phenytoin, ketamine, valproic acid, lacosamide) in blood and effluent on critically ill patients receiving CRRT in order to characterize drug pharmacokinetics and optimize dosing strategies in patients on CRRT.

Conditions Studied

Acute Kidney InjuryRenal InsufficiencyRenal FailurePharmacokinetics

Interventions

•Levetiracetam
•Lacosamide
•Phenytoin
•Phenobarbital
•Ketamine
•Valproic Acid

Eligibility

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Expected to be on CRRT and receive any of the following for more than 24 hrs
* Expected to survive for more than 24 hrs
* Achievement of steady state drug concentrations prior to study enrollment

Exclusion Criteria:

* Pregnancy
* Age \< 18
* Prisoner

Study Locations (1)

University of Maryland Medical Center

Baltimore, Maryland, United States