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Intranasal Esketamine and Fentanyl for Pain in Minor Trauma

NCT ID

NCT03421275

Target Enrollment

105 participants

Start Date

2017-12-01

Est. Completion

2022-12-01

About This Study

Intranasal esketamine, fentanyl and placebo are compared in treatment of acute pain in adult patients with minor trauma. Study is blinded randomized placebo-controlled parallel design.

Conditions Studied

Acute Pain Due to Trauma

Interventions

•Esketamine
•Fentanyl Citrate
•Saline Nasal

Eligibility

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* NRS 5 or more, minor trauma, no need for immediate iv cannulation, weight 45-115 kg

Exclusion Criteria:

* pregnancy, breastfeeding, head trauma, severe chronic obstructive pulmonary disease (COPD), gfr under 30, liver cirrhosis, mental illness other than mild/moderate depression, sleep apnea, unstable coronary artery disease (CAD), unstable heart failure (HF), intoxication, untreated hypertension, dementia, do not understand Finnish, contraindication to nasal spray, allergy to any of the medications, bradycardia, desaturation, suspected high intracranial pressure (ICP)

Study Locations (1)

Hyvinkää Hospital

Hyvinkää, Finland