CompletedN/Aketamine
Ketamine, Lidocaine and Combination for Postoperative Analgesia in Open Liver Resection
Sponsored by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
NCT ID
NCT03391427
Target Enrollment
124 participants
Start Date
2011-03-01
Est. Completion
2017-12-30
About This Study
Lidocaine and ketamine both are being used for perioperative analgesia. Perioperative lidocaine infusion has been shown to reduce postoperative pain and opioid consumption. Perioperative low dose Ketamine has shown improved postoperative pain and reduced opioid usage. We therefore tested the hypothesis that the combination would provide better analgesia in the milieu of intrathecal morphine.
Conditions Studied
Interventions
- •Lidocaine
- •Ketamine
- •Lidocaine+ketamine
- •Saline
Eligibility
Age:18 Years - 80 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * ASA physical status 2-4 * Elective major liver resection * Signed informed consent Exclusion Criteria: * ICU admission after surgery * tracheal extubation not planned after surgery * language barrier * mental impairment * severe coagulopathy * chronic pain or opioid dependance or both * alcohol/substance abuse * allergy to the study drugs * refusal for spinal * infection at site of spinal
Study Locations (1)
London Health Sciences Center
London, Ontario, Canada