Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects

Inclusion Criteria:

* Healthy adult male and female subjects between 18 and 55 years of age inclusive (at the time of initial informed consent)
* Body weight ≥ 45 and ≤ 87 kg
* Body Mass Index (BMI) ≥ 18 and ≤ 30 kg/m2

Exclusion Criteria:

* Female subjects who are pregnant, intend to become pregnant, or are breastfeeding
* History or presence of psychiatric or neurologic disease or condition
* History of first-degree relative with schizophrenia or mood disorder with psychosis
* History of alcohol or drug abuse
* History of recreational ketamine use, recreational PCP use, or an adverse reaction to ketamine
* History of violence
* Presence or positive history of significant medical illness, including high blood pressure, low blood pressure or orthostatic hypotension
* Any subjects who show subthreshold ketamine BOLD response
* Metal implants, pacemaker, other metal or paramagnetic objects contained within the body
* Claustrophobia
* Subject with any history of suicidal behavior or is currently at risk of suicide in the opinion of the investigator