Delirium Prevention With Ketamine in Ear, Nose, and Throat (ENT) Patients

About This Study

The goal of this prospective randomized double blinded placebo controlled study is to investigate if a single dose of ketamine in addition to standard anesthesia will reduce the risk of delirium in otolaryngeal cancer patients postoperatively. Ketamine's effect on post-operative pain and opioid use will be measured as well. Electroencephalogram (EEG) will be utilized during the surgical procedure to evaluate its potential as a possible predictive device for delirium.

Conditions Studied

Interventions

• •Ketamine
• •Placebo
• •Electroencephalogram (EEG)

Eligibility

Inclusion Criteria:

* Current diagnosis of otolaryngeal cancer and undergoing surgery with general anesthesia
* Competent to provide informed consent

Exclusion Criteria:

* Emergency surgery
* Monitored Anesthesia Care (i.e., regional anesthesia alone without plans for general anesthesia)
* Surgery involving the eye, eyebrow, forehead, or frontal scalp near the sensor placement
* Poor health literacy
* Allergy, or have experienced any drug reaction to ketamine
* Pregnant or lactating
* Currently in active alcohol withdrawal
* Taking buprenorphine for chronic pain

Study Locations (1)