The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy

About This Study

Recent clinical studies in abdominal surgery have shown that the use of Xylocaine® parenterally intraoperative at plasma concentrations below the toxic threshold of 5 .mu.g / ml, had an analgesic effect and decreased postoperative morphine consumption. This study aims to evaluate the activity of Xylocaine® and ketamine separately administered parenterally, in terms of postoperative morphine consumption and decrease incidences of postoperative chronic pain at 3 and 6 months after laparoscopic colectomy compared the placebo group. The evaluation of the intensity of postoperative pain, hyperalgesia perished skin surface scarring) and pain perception threshold by Pain Matcher® confirm or not the predictive nature of these criteria in the occurrence of chronic pain.

Conditions Studied

Interventions

• •Xylocaine
• •Ketamine
• •isotonic saline serum intravenous administration

Eligibility

Inclusion Criteria:

* Surgery: segmental or total colectomy performed by laparoscopy
* Anesthesia state 1 and 3

Exclusion Criteria:

* Patients classified Anesthesia state 4 or 5
* Allergy or intolerance to any of the products used in the protocol
* Creatinine clearance calculated by the Cockcroft formula below 50 ml / min
* Hepatocellular insufficiency
* Severe heart failure
* Peptic ulcer
* Chronic inflammatory bowel disease (IBD)
* Previous history of epilepsy or seizures
* Surgery emergency, palliative surgery, revision surgery
* Chronic pain requiring regular intake of analgesics include opioids
* Patients treated with lidocaine patch
* Psychic Disorder
* Additive Conduct vis-à-vis alcohol or mind-altering substances
* Pregnant or breastfeeding women

Study Locations (1)