TerminatedPhase 1ketamine

Ketamine and Magnesium in Post-operative Pain Control in Patients Treated With Opioids

NCT ID

NCT02940509

Target Enrollment

20 participants

Start Date

2017-07-01

Est. Completion

2018-02-27

About This Study

The goal of this research proposal is to determine if the intraoperative administrative of Ketamine and Magnesium during laparoscopic gynecologic surgery improves postoperative pain in patients on chronic opioid therapy for management of chronic pelvic pain.

Conditions Studied

Chronic Pain

Interventions

•Ketamine plus Magnesium sulfate
•Placebo

Eligibility

Sex:FEMALE

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

1. Subjects undergoing elective laparoscopic gynecologic surgery
2. Patients with chronic pelvic pain defined as pain that has persisted for more than 6 months in duration which is localized to the pelvis, anterior abdominal wall, lower back or buttocks and has leads to functional disability or medical care1
3. Patients requiring opioids daily for \>1 month
4. Consenting adults age 18-80
5. American Society of Anesthesiologists (ASA) Physical Status classification II to ASA III

Exclusion Criteria:

1. Patient refusal
2. Chronic Kidney disease (Creatinine\>2)
3. Patients treated with methadone
4. Known allergy or adverse effect of ketamine or magnesium
5. Patient unable to give informed consent
6. Patient with limited or no English fluency
7. Uncontrolled hypertension

Study Locations (1)

Milton S. Hershey Medical Center