CompletedPhase 4ketamine

Intravenous Sub-dissociative Dose Ketamine Injection Versus Infusion for Analgesia in the Emergency Department

NCT ID

NCT02916927

Target Enrollment

62 participants

Start Date

2016-09

Est. Completion

2017-04

About This Study

Objective: The purpose of this study is to determine if administering ketamine as an intravenous (IV) infusion over 15 minutes, as compared to an IV push, will decrease adverse drug reactions without attenuating its analgesic effects. Study design: prospective, randomized, controlled, double-blind trial.

Conditions Studied

Pain

Interventions

•Ketamine IV Infusion
•Ketamine IV push

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Pain NRS ≥5
* Anticipated stay in ED ≥1 hour

Exclusion Criteria:

* Pregnant or breast feeding
* Vital sign abnormalities (SBP \<90, SBP \> 180, HR \< 50, HR \> 150, RR \<10, RR \> 30, weight \<45 kg, weight \> 115 kg)
* Arrhythmias
* Altered mental status (active psychosis/delirium)
* Administration of opioid pain medication in previous 1 hour
* history of acute head or ocular trauma
* presence of known intracranial mass or vascular lesion

Study Locations (1)

Alameda Health System, Highland Hospital

Oakland, California, United States