WithdrawnPhase 4ketamine

Ketamine in Colorectal Surgery

NCT ID

NCT02785003

Start Date

2016-07

Est. Completion

2018-08

About This Study

This study will evaluate the effectiveness of ketamine infusions in the management of acute pain following open or laparoscopic colorectal surgery cases. Half of patients will receive the institutional standard of care and a placebo infusion (no active medication). The other half of patients will receive the institutional standard of care and a ketamine infusion. All subjects and staff will be blinded as to whether they are receiving placebo or ketamine.

Conditions Studied

Acute PainPain, PostoperativeColorectal Surgery

Interventions

•Placebo
•Ketamine
•Acetaminophen
•Opioid
•Alvimopan

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

1. Age greater than 18 years
2. Surgical intervention required for the management of colonic disease
3. Admission to either the acute care surgery or colorectal surgery service with an anticipated inpatient hospital stay of 72 hours.

Exclusion Criteria:

1. History of adverse reaction to ketamine
2. Chronic opioid therapy for \>3 weeks of \>30mg oral morphine equivalents per day
3. Known substance abuse with prescription opioids or heroin
4. Anticipated post-operative intubation (\>6hr duration)
5. History of psychosis
6. Active delirium
7. Glaucoma
8. Active acute coronary syndrome
9. Severe, poorly controlled hypertension (systolic blood pressure \> 180)
10. Concurrent use of monoamine oxidase inhibitors (MAOIs)
11. Pregnancy
12. Prisoners

Study Locations (1)

Froedtert Memorial Lutheran Hospital

Milwaukee, Wisconsin, United States