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The Role of Ketamine in Preventing Cognitive Dysfunctions in Postoperative Period of Cardiac Surgery

NCT ID

NCT02782429

Target Enrollment

50 participants

Start Date

2016-04

About This Study

The purpose of this study is to analyze the Ketamine with its anti-inflammatory profile would be able to prevent cognitive disorders in the postoperative period of cardiac surgery, since these disorders contribute to an impact on morbidity / mortality in this population.

Conditions Studied

DeliriumInflammationCognitive DisordersAmnesticDementia

Interventions

•Ketamine
•Saline

Eligibility

Age:50 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Patients aged over 50 years.
* Be submitted to cardiac surgery by sternotomy and with the use of cardiopulmonary bypass (CPB).
* American Society of Anesthesiologists classification 1, 2,3 and 4.

Exclusion Criteria:

* Patients undergoing reoperation.
* Patients undergoing heart transplantation.
* Patients using vasopressor agents and / or ionotropic continuous preoperatively.
* Patients with prior endotracheal intubation and consequently Ventilatory Assistance Mechanics.
* Patients with documented psychiatric disorders.
* Patients with previous cognitive disorders.
* Patients with a history of alcohol or drug abuse.
* Patients with a history of cerebrovascular accident (CVA) with less than 3 months.

Study Locations (1)

Instituto de Medicina Integral Prof Fernando Figueira