UnknownPhase 2ketamine
Positron Emission Tomography Assessment of Ketamine Binding of the Serotonin Transporter
Sponsored by Medical University of Vienna
NCT ID
NCT02717052
Target Enrollment
74 participants
Start Date
2016-05
Est. Completion
2019-12-31
About This Study
The study at hand is the first to investigate ketamine's SERT binding in humans, by utilizing the highly selective SERT radioligand \[11C\]DASB and positron emission tomography.
Conditions Studied
Interventions
- •(S)-ketamine (Main study)
- •(S)-ketamine (Pilot II)
- •(R,S)-ketamine (Pilot II)
- •Placebo
- •PILOT Study II: PET1
- •PILOT Study II: PET2
- •Main Study: PET1
- •Main Study: PET2
- •PILOT Study I: PET1
- •PILOT Study I: PET2
- •(R,S)-ketamine (Pilot I)
- •(R,S)-ketamine (Pilot III)
- •PILOT Study III: PET1
- •PILOT Study III: PET2
Eligibility
Age:18 Years - 55 Years
Healthy Volunteers:Yes
View full eligibility criteria
Inclusion Criteria: * 18-55 years * somatic health * severe unipolar depression according to DSM-IV (SCID) und HAM-D (for patients) * capable of giving informed consent * negative pregnancy test (females) Exclusion Criteria: * severe somatic illness * psychiatric disorder (for healthy controls) * an axis I comorbidity other than MDD , other than anxiety symptoms (for patients) * clinically relevant alterations in blood draw, ecg, and somatic testing * substance dependency disorder * intake of psychopharmacological medication in last 6 months * first degree relative with Axis 1 disorder (for Pilot I study)
Study Locations (1)
Department of Psychiatry and Psychotherapy, Medical University of Vienna
Vienna, Austria