Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

About This Study

Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.

Conditions Studied

Interventions

• •Nefopam
• •Ketamine
• •Saline

Eligibility

Inclusion Criteria:

* patient who scheduled laparoscopic cholecystectomy under general anesthesia
* American Society of Anesthesiologist(ASA) class I or II
* adult patient (age 20 - 65)

Exclusion Criteria:

* patient who has liver disease
* patient who has kidney disease
* patient who has diabetes mellitus(DM) or heart disease
* patient who takes opioid or beta-blocker
* patient who has airway disease
* patient who has allergy with the drug

Study Locations (1)