CompletedN/Aketamine

Cognitive Biases Under Ketamine

Sponsored by Centre Hospitalier St Anne

NCT ID
NCT02235012
Target Enrollment
84 participants
Start Date
2014-09-08
Est. Completion
2022-04-29

About This Study

Characterise cognitive biases resulting from low dose ketamine infusion, used as a pharmacological model of psychosis. Our assumption is that low dose ketamine results in reasoning biases by impairing the way uncertainty is monitored and taken into account for decision making.

Conditions Studied

Healthy Subjects

Interventions

  • Ketamine
  • Placebo

Eligibility

Age:18 Years - 39 Years
Healthy Volunteers:Yes
View full eligibility criteria
Inclusion Criteria:

* Right-handed (as assessed by the Edinburgh scale)
* Aged 18 to 39
* Having given an informed consent
* Health insurance

Exclusion Criteria:

* Pregnant or breastfeeding woman (a urine pregnancy test will be offered in doubt)
* Personal or first-degree family history of psychosis
* Personal history of mood disorder, anxiety disorder, obsessive-compulsive disorder, somatoform disorder, dependence on a psychoactive substance, behavior disorder incompatible with a 2 hours EEG recording.
* Psychotropic treatment, current or stopped for less than 1 month, including antidepressant, anxiolytic but excluding hypnotic treatments.
* Personal history of neurologic disorder in relation to the central nervous system : congenital malformation of the brain, brain tumor, multiple sclerosis, degenerative disease of the central nervous system, epilepsy, current or in remission for less than 3 years or still requiring a medical treatment, inflammatory disease of the central nervous system dating under a year or having resulted in sequelae.
* Known hypertension or blood pressure above 140/90 mmHg upon clinical examination, congenital heart disease, ischemic heart disease, cardiac insufficiency, supraventricular and ventricular heart rhythm disorder.
* Person with restricted liberty, as a result of judicial or administrative measures
* Persons under involuntary commitment as a result of a psychiatric disorder.
* Person subject to a measure of legal protection or unable to consent.
* Known intolerance ketamine.

Study Locations (1)

Centre Hospitalier Sainte Anne
Paris, France

This trial is not recruiting

This study has completed enrollment. Check back for results or find similar trials.

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Data Source
ClinicalTrials.gov

Last updated from source