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Ketamine and Glutamate After Brain Injury : a Microdialysis Study
Sponsored by Pierre-Julien CUNGI
NCT ID
NCT02232347
Target Enrollment
20 participants
Start Date
2014-10
Est. Completion
2017-05
About This Study
The objective of the study is to compare the effects of 48 hours ketamine infusion versus sufentanil infusion on brain glutamate concentrations measured with microdialysis after traumatic brain injury. We hypothesize that ketamine infusion will decrease high glutamate values faster than sufentanil.
Conditions Studied
Interventions
- •Ketamine
- •Sufentanil
Eligibility
Age:18 Years - N/A
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * \> 18 years old * Glasgow Coma Scale (GCS) \< 9 * \> 3 days of sedation expected at the arrival Exclusion Criteria: * pregnancy * \< 18 years old * estimated survival \< 48 hours post-trauma * expected sedation \< 3 days * coagulation impairment (platelets\<100.000/mm3 and prothrombin time (TP) \<60%) * Cardiac arrest before ICU admission * Admission \> 12 hours after trauma * Multimodal monitoring implanted \> 24 hours post trauma * Participation to the study refused by the next of kind * No next of kind
Study Locations (1)
Sainte Anne Military Teaching Hospital
Toulon, France