TerminatedN/Aketamine

Comparison of Outcomes During MRI Sedation With Midazolam-dexmedetomidine Versus Ketamine-dexmedetomidine

NCT ID

NCT02129426

Target Enrollment

21 participants

Start Date

2014-08

Est. Completion

2018-03

About This Study

This study will compare 2 different sedation drugs (Ketamine and Midazolam) when they are used with another sedating medicine called Dexmedetomidine for MRI sedation. This study hopes to measure the impact each drug has on what happens during and after MRI sedation with Dexmedetomidine

Conditions Studied

Sedation

Interventions

•Ketamine
•Midazolam
•Dexmedetomidine

Eligibility

Age:N/A - 18 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

1. Inpatient at Kosair Children's Hospital.
2. Order placed by treating team for MRI of the brain with sedation.
3. Age less than or equal to 18 years.
4. Plan to sedate with dexmedetomidine, regardless of study participation.

Exclusion Criteria:

1. Previous adverse reaction to dexmedetomidine or clonidine
2. Current use of clonidine as a routine medication
3. Concurrent use of a heart-rate decreasing medication (digoxin, propranolol)
4. Contraindication to ketamine use

   * Intracranial hypertension or traumatic brain injury
   * Intraocular hypertension of eye trauma
   * Pulmonary hypertension requiring medical management
5. Planned additional procedure during the sedation encounter (non-brain MRI, lumbar puncture, EEG etc)

Study Locations (1)

University of Louisville

Louisville, Kentucky, United States