CompletedPhase 4ketamine

ACL Repair and Multimodal Analgesia

NCT ID

NCT01868425

Target Enrollment

112 participants

Start Date

2013-04

Est. Completion

2017-12

About This Study

This study will evaluate the effectiveness of an aggressive multimodal regimen versus standard multimodal for Anterior Cruciate Ligament (ACL) repair using hamstring graft for patients having surgery in our outpatient surgicenter.

Conditions Studied

Pain

Interventions

•multimodal:acetaminophen, gabapentin, ketamine, bupivacaine
•placebo pills and injectables

Eligibility

Age:18 Years - 55 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Patients of orthopedic surgeons on the study team scheduled for ACL repair using hamstring graft from the same leg will be considered for inclusion in this study. Other inclusion criteria are as follows:

  * American Society of Anesthesiologists (ASA) physical status 1-3
  * BMI of \< 40 kg/m2
  * Consents to general anesthesia and pre-operative femoral nerve block for case

Exclusion Criteria:

* Any contraindication to a femoral nerve block
* Allergy to local anesthetics, nonsteroidal anti-inflammatory medications, ketamine, acetaminophen, hydromorphone, oxycodone
* Peripheral or central nervous system disease
* Renal or hepatic impairment
* History of opioid dependence or current regular narcotic use
* Significant psychiatric disease
* Pregnancy or lactation (by verbal report)
* Seizure Disorder
* History of post-operative nausea and vomiting
* Latex allergy
* Clinically significant cardiac or pulmonary disease

Study Locations (1)

University of Wisconsin

Madison, Wisconsin, United States