Developing Anesthesia as Post Traumatic Stress Disorder (PTSD) Therapy

About This Study

This preclinical phase 1 development study in healthy volunteers seeks to identify if low doses of commonly used non-triggering anesthetic agents might have clinical utility for modulating emotional memory processing and to understand the nature of the brain mechanisms of drug action. Optimally, a drug, dose and brain mechanism of action will be identified that will form the foundation for future use in clinical studies of patients with PTSD.

Conditions Studied

Interventions

• •Dexmedetomidine
• •Propofol
• •Ketamine
• •Nitrous Oxide
• •Placebo

Eligibility

Inclusion Criteria:

* Healthy adults.
* Between the ages of 18 and 35.

Exclusion Criteria:

* Pregnancy.
* Left-handed.
* Unusual facial anatomy.
* History of esophageal reflux.
* Respiratory problems.
* Central nervous system disorders.
* Cardiovascular problems.
* Kidney disease.
* Diabetes.
* History of Substance abuse.
* History of adverse anesthetic reactions.
* Hepatitis.
* Failure to pass MRI screening questionnaire.
* Fear of small-enclosed spaces.
* Mental illness.
* Non-native English speakers.

Study Locations (1)