Perioperative Opioid-induced Hyperalgesia and Its Prevention With Ketamine and Methadone

About This Study

Background: In perioperative period inhibition of N-Methyl-D-Aspartate receptor prevents opioid-induced hyperalgesia and reduce postoperative opioid requirement after abdominal surgery. Methadone is both a µ-opioid receptor agonist like Morphine and a N-Methyl-D-Aspartate antagonist. Study Aim. To evaluate the efficacy of intraoperative Ketamine and postoperative Methadone analgesia in preventing opioid-induced hyperalgesia after abdominal surgery.

Conditions Studied

Interventions

• •ketamine infusion
• •Methadone PCA

Eligibility

Inclusion Criteria:

* patients undergoing open colo-rectal surgery

Exclusion Criteria:

* ASA status more than II, history of chronic pain, ischemic heart disease or chronic pulmonary disease, allergy to any drugs used in the protocol. Body Max Index more than 35.

Study Locations (1)