CompletedPhase 4ketamine

Preventing Pain After Heart Surgery

NCT ID

NCT01480765

Target Enrollment

150 participants

Start Date

2011-12-12

Est. Completion

2013-03-07

About This Study

The use of pre-emptive analgesia to prevent pain following sternotomy for cardiac surgery

Conditions Studied

PainHyperalgesiaChronic IllnessNeuropathic Pain

Interventions

•Pregabalin
•Ketamine infusion
•Placebo capsules
•Placebo infusion

Eligibility

Age:18 Years - 80 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Informed Consent
* First time sternotomy for all cardiac surgery
* Patient aged 18 - 80 years

Exclusion Criteria:

* Emergency surgery (decision to operate taken on the day of surgery)
* Previous sternotomy
* Preoperative renal failure (eGFR \<60 ml/min)
* History of chronic non-anginal pain
* Chronic pain medication other than paracetamol and non-steroidal anti-inflammatory drugs
* Concurrent use of oxycodone, lorazepam, or ethanol.
* Concurrent use of any drugs for neuropathic pain e.g. antiepileptics, antidepressants
* Allergy to pregabalin, gabapentin or ketamine
* Pregnancy
* Limited understanding of numerical scoring scales
* Previous participation in other trials investigating analgesic agents or any IMP in previous three months

Study Locations (1)

Pain and Ananesthesia Research Centre, Barts and The London NHS Trust