CompletedPhase 4ketamine
Alternative Sedation During Bronchoscopy
Sponsored by University of Pennsylvania
NCT ID
NCT01158820
Target Enrollment
50 participants
Start Date
2010-06
Est. Completion
2012-05
About This Study
This protocol hopes to determine whether the use of dexmedetomidine-ketamine can reduce the use of standard of care fentanyl-midazolam sedation during bronchoscopy. This may result in less respiratory depression while providing better compliance with the procedure.
Conditions Studied
Interventions
- •Dexmedetomidine load
- •Ketamine load
- •Midazolam load
- •Fentanyl load
- •Dexmedetomidine maintenance
- •Ketamine maintenance
- •Midazolam demand
- •Fentanyl demand
- •Benadryl demand
Eligibility
Age:18 Years - 90 Years
Healthy Volunteers:No
View full eligibility criteria
Inclusion Criteria: * Adults over the age of 18 scheduled for elective flexible bronchoscopy in the endoscopy suite or OR of HUP Exclusion Criteria: * History of inability to complete bronchoscopy attributable to inadequate sedation * Requiring more than 2 LPM supplemental oxygen to maintain SaO2 \> 90% * History of allergy to study medications * Pregnancy * A history of psychosis * Any condition deemed likely by the pulmonologist or anesthesiologist to pose a significant risk due to elevation of blood pressure, including cerebral/aortic aneurysm, and or ischemic cardiovascular disease * Bradydysrhythmia deemed significant by the anesthesiologist or pulmonologist * A diagnosis of significant renal or hepatic impairment
Study Locations (1)
University of Pennsylvania
Philadelphia, Pennsylvania, United States