TerminatedN/Aketamine

Lidocaine and Ketamine in Abdominal Surgery

NCT ID

NCT00721110

Target Enrollment

64 participants

Start Date

2008-07

Est. Completion

2012-07

About This Study

This study is being done to determine if combined infusions of lidocaine and ketamine is better than a lidocaine or ketamine infusion alone, or to placebo in improving recovery after abdominal hysterectomy. Participants will be randomized into one of four groups. Evaluations will be done through walking tests, pain and fatigue questionnaires and blood tests.

Conditions Studied

Abdominal Hysterectomy (& Wertheim)

Interventions

•Lidocaine
•Placebo
•Ketamine
•Ketamine + Lidocaine

Eligibility

Sex:FEMALE

Age:18 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Age greater than 18 years old and less than 75 years years old
* Horizontal abdominal incision

Exclusion Criteria:

* Emergency or urgent procedure
* Preexisting chronic pain (at any site) requiring treatment
* Contraindication to any study medication (ketamine or lidocaine)
* History of significant Axis I psychiatric disease (major depressive disorder, bipolar disorder, schizophrenia, etc.)
* Significant hepatic (ALT or AST \> 2 times normal) or renal (serum creatinine \> 2 mg/dl) impairment
* Seizure disorder requiring medication within past 2 years
* Planned spinal or epidural anesthesia or analgesia

Study Locations (1)

Cleveland Clinic/Hillcrest Hospital

Mayfield Heights, Ohio, United States