TerminatedN/Aketamine

Lidocaine and Ketamine Versus Standard Care on Acute and Chronic Pain

NCT ID

NCT00720330

Target Enrollment

12 participants

Start Date

2008-07

Est. Completion

2010-02

About This Study

The investigators are conducting this study to find out if intravenous (injected through the vein) infusion of lidocaine and ketamine administered with general anesthesia is as effective as a paravertebral block in lessening pain after surgery and that both of these techniques are superior to general anesthesia alone in reducing pain immediately after surgery and in the long-term.

Conditions Studied

PainNausea

Interventions

•ropivacaine
•Lidocaine/Ketamine
•placebo

Eligibility

Sex:MALE

Age:18 Years - 75 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Age greater than 18 and less than 75 years
* Male
* Unilateral inguinal hernia scheduled for elective open repair

Exclusion Criteria:

* Incarcerated hernia or urgent procedure
* Reoperation (recurrent hernia)
* Contraindication to regional anesthesia such as:
* Coagulopathy
* Infection at the site of needle insertion
* Pre-existing chronic pain (at any site) requiring treatment
* Contraindication to any study medication (local anesthetic or ketamine)
* History of significant Axis I psychiatric disease (major depressive disorder,bipolar disorder, schizophrenia, etc.)
* Significant hepatic (ALT or AST \> 2 times normal) or renal (serum creatinine \> 2 mg/dl) impairment

Study Locations (1)

Cleveland Clinic/Hillcrest Hospital