Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy

About This Study

Lung surgery under thoracotomy is known to induce long-term pain which can be considered as neuropathic in many patients concerned \[1,2\]. The suspected origin of neuropathy is a direct traumatism of intercostal nerve(s) \[3\]. Among the possible preventive treatments that can be administered during the initial aggression, ketamine \[4,5\] appears as the easiest to use, as it is already commonly administered intra and postoperatively for improvement of analgesia \[6\].

Conditions Studied

Interventions

• •Hypothetica

Eligibility

Inclusion Criteria:

* elective partial pneumonectomy under lateral or posterolateral thoracotomy, performed under standardized general anesthesia.

Exclusion Criteria:

* Patient's refusal
* Bad health status
* Previous neuropathic pain or treatment acting on neuropathic pain
* Major postoperative complication
* Intolerance to ketamine
* Epidural anesthesia

Study Locations (1)