TerminatedN/Aketamine

Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function

NCT ID

NCT00229567

Target Enrollment

60 participants

Start Date

2005-09

Est. Completion

2006-11

About This Study

Bowel function after bowel surgery is delayed (postoperative ileus)by both opiates and the surgery itself. We hypothesized that decreasing opiate use by other analgesics will speed the return of bowel function after surgery. Lidocaine and Ketamine are drugs that appear to be synergistic and do not slow peristalsis. This study is a Randomised Controlled Trial of Lidocaine Infusion Plus Ketamine Injection versus Placebo to to determine whether they will decrease opiate use and then whether decreased opiate use will speed the return of bowel function.

Conditions Studied

Colorectal Cancer

Interventions

•Lidocaine infusion plus ketamine injection

Eligibility

Age:18 Years - 79 Years

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* age 18 to 79
* booked for urgent or elective colon surgery undergoing a left, right, or transverse hemicolectomy via laparotomy

Exclusion Criteria:

* patients requiring emergency surgery
* pregnant subjects or those who might be pregnant
* subjects allergic to lidocaine, ketamine, morphine, naproxen, or acetaminophen
* subjects with epidural analgesia
* subjects unable to understand and implement a Patient-Controlled Intravenous Analgesia system
* subjects who do not know English well enough to understand the consent form and assessments
* subjects with known hepatic or renal failure or cardiac dysrhythmias or atrioventricular block
* patients with pre-existing functional bowel motility disorders including Crohn's disease and ulcerative colitis
* daily use of laxatives, inability to have a bowel movement without laxatives, use of suppositories or enemas on a daily basis, or use of antimotility agents
* patients with Parkinson's disease

Study Locations (1)

Saskatoon Health Region, 410 22nd Street East

Saskatoon, Saskatchewan, Canada