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Psychedelic Clinical Trials

Find clinical trials studying psilocybin, MDMA, ketamine and other psychedelics. Many trials are actively recruiting participants who haven't found relief from conventional treatments.

Showing 97144 of 267 trials
Completed·Phase 1·ketamine

Cognitive Behavioral Therapy in Prolonging the Antidepressant Effects of Intravenous Ketamine

Yale University

Depression
Completed·Phase 1·ketamine

Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

VA Office of Research and Development

Major Depressive DisorderAlcohol Use Disorder
Completed·Early Phase 1·ketamine

A Multimodal Neuroimaging Study of Brain Activation Patterns Under Ketamine

Psychiatric University Hospital, Zurich

Major Depressive Disorder
Completed·Phase 2·ketamine

Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)

Massachusetts General Hospital

Treatment Resistant Depression
Completed·Phase 2·ketamine

Ketamine for Depression and Suicide Risk

Mayo Clinic

DepressionSuicide
Completed·Phase 2·ketamine

Ketamine in Adolescents With Treatment-Resistant Depression

University of Minnesota

Major Depressive Disorder
Completed·Phase 1·ketamine

Biomarkers of Fast Acting Therapies in Major Depression

University of California, Los Angeles

Major Depressive Disorder
Completed·Phase 2·ketamine

A Double-blind Study to Assess the Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of the Symptoms of Major Depressive Disorder, Including Suicidal Ideation, in Participants Who Are Assessed to be at Imminent Risk for Suicide

Janssen Research & Development, LLC

Major Depressive Disorder
Completed·Phase 2·ketamine

Ketamine as a Rapidly-Acting Antidepressant in Depressed Emergency Department Patients

NYU Langone Health

Depression
Completed·Phase 4·ketamine

Comparing Ketamine and Propofol Anesthesia for Electroconvulsive Therapy

University of Saskatchewan

Treatment Resistant Depression
Completed·Early Phase 1·ketamine

Examining The Effect Of Ketamine On Glutamate/Glutamine Cycling

Yale University

Depression
Completed·Phase 2·ketamine

Ketamine Plus Lithium in Treatment-Resistant Depression

Icahn School of Medicine at Mount Sinai

Depression
Completed·N/A·ketamine

Ketamine Versus Placebo for Treatment Resistant Major Depressive Disorder

Massachusetts General Hospital

Major Depressive Disorder
Completed·Phase 2·ketamine

A Study of Ketamine in Patients With Treatment-resistant Depression

Janssen Research & Development, LLC

Major Depressive Disorder
Completed·Phase 2·ketamine

A Study of the Efficacy of Intravenous Esketamine in Adult Patients With Treatment-Resistant Depression

Janssen Research & Development, LLC

Major Depressive Disorder
Completed·N/A·ketamine

PET Imaging of mGLuR5 With Drug Challenge

Yale University

Major Depressive DisorderPost-Traumatic Stress Disorder (PTSD)
Completed·Phase 4·ketamine

Ketamine in the Treatment of Suicidal Depression

New York State Psychiatric Institute

Major Depressive DisorderSuicidal Ideation
Completed·N/A·ketamine

Treatment of Suicidal Ideation With Intravenous Ketamine Infusion

University of Alabama at Birmingham

DepressionSuicidal Ideation
Completed·N/A·ketamine

Ketamine Infusion for Treatment-resistant Major Depressive Disorder

Massachusetts General Hospital

Major Depressive Disorder
Completed·Phase 3·ketamine

Estimate the Efficiency of the Association of an Injection of Ketamine and the Venlafaxine in the Severe Major Depressive Disorder for Six Weeks

University Hospital, Grenoble

Major Depressive Disorder
Completed·Phase 1·ketamine

Ketamine for Depression and Alcohol Dependence

Yale University

DepressionAlcohol Dependence
Completed·Phase 2·ketamine

Ketamine in the Treatment of Depression

Columbia University

Major Depressive Disorder
Completed·N/A·ketamine

Intranasal Ketamine in Treatment-Resistant Depression

James Murrough

Major Depressive Disorder
Completed·N/A·ketamine

MRI Studies of Emotion in Depression

Icahn School of Medicine at Mount Sinai

Major Depressive Disorder
Completed·N/A·ketamine

Ketamine Anesthesia in Electroconvulsive Therapy

Mayo Clinic

Depression
Completed·Phase 4·ketamine

The Use of Ketamine as an Anaesthetic During Electroconvulsive Therapy

University of Aberdeen

Depression
Completed·N/A·ketamine

Neuromodulation to Facilitate the Effect of Ketamine

The Neuroscience Center, LLC

DepressionChronic PainSubstance Abuse
Completed·Phase 4·ketamine

Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression

Northwell Health

Unipolar DepressionBipolar Depression
Completed·Phase 1·ketamine

Ketamine for Low Mood States in the ER

Yale University

DepressionSuicide Ideation
Completed·Phase 1·ketamine

Study Where Pharmaco Magnetic Resonance Imaging (MRI) Effects of AZD6765 Will be Compared to Placebo in Depressive Male and Female Subjects

AstraZeneca

Depression
Completed·Phase 2·ketamine

Ketamine as a Rapid Treatment for Post-traumatic Stress Disorder (PTSD)

Dennis Charney

Stress Disorders, Post-TraumaticPTSDDepression+1 more
Completed·Phase 1·ketamine

Continuation Ketamine in Major Depression

James Murrough

Major Depressive Disorder
Completed·Phase 4·ketamine

Memantine Augmentation of Antidepressants

University of Massachusetts, Worcester

Depressive Disorder
Completed·Phase 1·ketamine

Rapid Antidepressant Effects of Ketamine in Major Depression

National Institute of Mental Health (NIMH)

DepressionMood DisordersMajor Depresssion
Enrolling by Invitation·Phase 3·psilocybin

Phase III Long-term Extension Trial to Assess Safety and Efficacy of CYB003 in MDD (EXTEND)

Cybin IRL Limited

Major Depressive Disorder
Enrolling by Invitation·N/A·ketamine

Assess the Utility of a Speech-based Machine Learning Algorithm to Predict Treatment Response to Psychiatric Interventions

Psyrin Inc.

Obsessive Compulsive Disorder (OCD)Bipolar DisordersMajor Depressive Disorder+2 more
Enrolling by Invitation·N/A·ketamine

Cognitive Training as an Adjunct to Ketamine in Real-world Clinics

University of Pittsburgh

Depression
Enrolling by Invitation·N/A·ketamine

Using Virtual Reality to Control the Audio-visual Inputs During Ketamine/Esketamine Treatment

Yale University

Depression
Enrolling by Invitation·N/A·ketamine

Long Term Follow Up KET-PD

Yale University

Parkinson's DiseaseDepression
Enrolling by Invitation·N/A·ketamine

Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements

Kernel

DepressionMajor Depressive Disorder
Enrolling by Invitation·N/A·ketamine

Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)

Medical University of Gdansk

Major Depressive DisorderPost Traumatic Stress DisorderObsessive-Compulsive Disorder+3 more
Not Yet Recruiting·Phase 1·psilocybin

Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder

Indiana University

Treatment Resistant DepressionSubstance Use Disorders
Not Yet Recruiting·Phase 3·ketamine

InTRavenous kEtAmine and immerSive virtUal Reality to Treat dEpression

Sunnybrook Health Sciences Centre

Treatment Resistant Depression
Not Yet Recruiting·N/A·ketamine

Effect of Continuous Intraoperative Esketamine Infusion on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Mild-to-Severe Depression

Chinese PLA General Hospital

DepressionAnxietyS-ketamine+1 more
Not Yet Recruiting·N/A·ketamine

Effect of Esketamine on Perioperative Negative Emotions in Breast Cancer Surgery Patients With Severe Depression

Chinese PLA General Hospital

DepressionAnxietyS-ketamine+1 more
Not Yet Recruiting·Phase 3·ketamine

Comparison of Esketamine Nasal Spray vs.Aripiprazole in Treat.Resistant Major Depressive Disorder in Elderly Patients

Fundación Pública Andaluza para la gestión de la Investigación en Sevilla

Depressive Disorder
Not Yet Recruiting·Phase 3·ketamine

Evaluation of the Efficacy and Safety of Subcutaneous Ketamine in the Treatment of Depressive Episode With Suicidal Ideation and/or Behavior in Adolescents

Federal University of São Paulo

Depressive DisorderSuicidal Ideas
Not Yet Recruiting·Phase 1·ketamine

Ketamine for Combined Depression and Alcohol Use Disorder

University Hospital of North Norway

DepressionAlcohol Use Disorder
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How to Join a Clinical Trial

Clinical trials are research studies that test new treatments. Participating can give you access to cutting-edge therapies while contributing to medical science. Each trial has specific eligibility criteria based on the research goals.

1. Review

Read the trial details, eligibility criteria, and what participation involves.

2. Contact

Reach out to the study team using the contact information provided.

3. Screen

Complete the screening process to determine if you're eligible.