Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants

Inclusion Criteria:

1. Age between 18 and 75 years old
2. Sufficient understanding of the German language
3. Understanding of procedures and risks associated with the study
4. Willing to adhere to the protocol and signing of the consent form
5. Willing to refrain from the consumption of illicit psychoactive substances during the study
6. Willing not to operate heavy machinery for 48 hours after the study session.
7. Willing to use effective birth control throughout study participation
8. Body mass index between 18-34.9 kg/m2

Exclusion Criteria:

1. Relevant chronic or acute medical condition
2. Any implanted medical devices (e.g., pacemakers, neurostimulators, or metal prostheses)
3. Current or previous major psychiatric disorder (e.g. bipolar disorder, schizophrenia), current depression or anxiety disorder.
4. Psychotic disorder or bipolar disorder in first-degree relatives
5. Hypertension (SBP\>140/90 mmHg) or hypotension (SBP\<85 mmHg)
6. Lifetime use of MDMA on more than 20 occasions or any use within the previous two months
7. Pregnancy or current breastfeeding
8. Participation in another clinical trial (currently or within the last 30 days)
9. Use of medication that may interfere with the effects of the study medication
10. Tobacco smoking (\>10 cigarettes/day)
11. Consumption of alcoholic beverages (\>15 drinks/week)