Efficacy of Propofol Combination With Either Ketamine, Dexmedetomidine or Midazolam for Sedation During Upper Gastrointestinal Endoscopic Procedures

Inclusion Criteria:

* Both male and female patients aged between 18 and 65 years
* Patients who are scheduled for elective upper gastrointestinal endoscopic procedures with sedation
* Patients who are classified as ASA (American Society of Anesthesiologists) I and II

Exclusion Criteria:

* Patient's refusal to participate
* Respiratory compromise as patients with respiratory failure or with active chest conditions, e.g., bronchial asthma or pneumonia
* Cardiovascular compromise including heart failure and shocked patients
* Severe uncontrolled hematemesis with shock or risk of aspiration.
* Patients who are allergic or have any contraindications to any of the used drugs.
* Patients who have a chronic neuropsychiatric disorder or are on a neuropsychiatric drug.
* Patients on long-term sedative medication have a history of drug or alcohol abuse.
* Pregnancy and lactation