RecruitingEarly Phase 1LSD
Mood Effects of Serotonin Agonists: Depression
Sponsored by University of Chicago
NCT ID
NCT07017478
Target Enrollment
48 participants
Start Date
2025-06-09
Est. Completion
2026-06-01
About This Study
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.
Conditions Studied
Interventions
- •LSD
- •Placebo
Eligibility
Age:18 Years - 40 Years
Healthy Volunteers:Yes
View full eligibility criteria
Inclusion Criteria: * English Fluency * high school education or higher * BMI between 19-30 kg/m2 Exclusion Criteria: * individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease) * high blood pressure (\>140/90) * current suicidal ideation or suicide attempt in past 12 months * past year severe substance use disorder * personal or first-degree relative with history of psychosis * currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks) * active panic disorder * severe obsessive-compulsive disorder * severe post-traumatic stress disorder * women who are pregnant or planning to become pregnant
Study Locations (1)
University of Chicago
Chicago, Illinois, United States