RecruitingN/Aketamine

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

NCT ID

NCT06995690

Target Enrollment

30 participants

Start Date

2025-06-01

Est. Completion

2025-11-01

About This Study

This randomized, double-blind, controlled clinical trial investigates the efficacy of a sub-anesthetic dose of ketamine (0.5 mg/kg IV) in preventing post-spinal hypotension in patients undergoing elective orthopedic surgeries under spinal anesthesia. The study compares ketamine with placebo (normal saline) in terms of blood pressure stability and incidence of hypotensive episodes following spinal anesthesia.

Conditions Studied

Post-spinal HypotensionOrthopedic SurgerySpinal Aneshtesia

Interventions

•Ketamine
•Normal Saline

Eligibility

Age:18 Years - N/A

Healthy Volunteers:No

View full eligibility criteria

Inclusion Criteria:

* Patients American Society of Anesthesiologists Physical Status (ASA) I to II undergoing orthopedic surgeries under spinal anesthesia.
* Both Sexes.
* Patients aged equal to or above 18 years.
* Body mass index \<35 kg/m2
* Duration of operation from 1 hour to 3 hours

Exclusion Criteria:

* Patients' refusal of procedure or participation in the study.
* Patients with contraindication to spinal anesthesia.
* Patients with cardiovascular or pulmonary disease.
* Patients with pre-procedural hypotension (systolic arterial pressure less than 90 mmHg and/or mean arterial pressure less than 60 mmHg).
* Patients aged below 18 years.
* Duration of operation below 1 hour or above 3 hours.

Study Locations (1)

Ain Shams University Hospitals